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US 12,582,302 B2Granted
Apparatus, systems and methods for in vivo imaging
AssigneeThe Regents of the University of California
InventorsMoshiur M. Anwar, Catherine Park, Bernhard Boser
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Abstract
The disclosed apparatus, systems and methods relate to the use of optical nanoparticles in the illumination and imaging of tissues such as cancer tissues. Optical nanoparticles such as upconverting nanoparticles can be introduced into a patient and illuminated at a first time and wavelength and then imaged at a second time and wavelength to improve resolution and reduce imager size.
Claims26
An imaging system, comprising:
- a. an imaging chip comprising a silicon substrate and a plurality of pixels, the imaging chip being configured for through-illumination with light transmitted through the silicon substrate, wherein the imaging chip comprises circuitry configured to mitigate or compensate for electrical interference generated in the silicon substrate by illumination passing through the substrate;
- and
- b. a composition comprising at least one optical nanoparticle wherein the imaging chip is constructed and arranged to detect light emission from the at least one nanoparticle, wherein the at least one nanoparticle comprises an upconverting nanoparticle (UCNP) that upconverts near-infrared light to higher energy light.
A method of imaging disease tissue, comprising:
- a) introducing a composition comprising at least one optical nanoparticle into tissue, wherein the at least one nanoparticle comprises an upconverting nanoparticle (UCNP) that upconverts near-infrared light to higher energy light;
- b) illuminating the at least one optical nanoparticle via through-illumination of an imaging chip comprising a silicon substrate, the illuminating comprising illuminating with a pulse of light directed through the silicon substrate of the imaging chip, the light having a wavelength in the near-infrared or infrared range;
- c) mitigating substrate carriers generated in the silicon substrate;
- and
- d) after the pulse of near-infrared light has ceased, recording luminescence of the at least one optical nanoparticle with an imaging chip.
2 more elements
An imaging system, comprising:
- a. an imaging chip comprising a silicon substrate and a plurality of pixels, the imaging chip being configured for through-illumination with light transmitted through the silicon substrate, wherein the imaging chip comprises circuitry configured to mitigate or compensate for electrical interference generated in the silicon substrate by illumination passing through the substrate;
- and
- b. a composition comprising at least one optical nanoparticle wherein the imaging chip is constructed and arranged to detect light emission from the at least one nanoparticle, wherein the imaging system is lensless.
Dependencies are inferred from the claim text.