Method for prognosis prediction of skin cancer and use thereof
AssigneePublic University Corporation Nagoya City University
InventorMotoki Nakamura
Life of this patent
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Abstract
Provided is a technique of predicting prognosis of skin cancer. A method for prognosis prediction of skin cancer includes: a step of obtaining a correlation amount correlated with an expression level of a glucose-6-phosphate dehydrogenase in a sample collected from a patient with the skin cancer; and a step of determining that the prognosis of the skin cancer is poorer when the correlation amount is large than that when the correlation amount is small.
Claims11
A method of treating skin cancer in a patient, comprising determining the expression level of a glucose-6-phosphate dehydrogenase in a tumor sample collected from said patient by immunohistostaining of the sample, and administering an immune checkpoint inhibitor to said patient if the expression level of said glucose-6-phosphate dehydrogenase is determined by immunohistostaining of the sample to be less than 50% of the staining rate, wherein the immune checkpoint inhibitor is an anti-PD-L1 antibody or an anti-PD-1 antibody.
A method of treating skin cancer in a patient, comprising determining the expression level of a glucose-6-phosphate dehydrogenase in a sample collected from said patient by immunohistostaining of the sample based on an antigen-antibody reaction using an anti-G6PD antibody or a fragment thereof, and administering an immune checkpoint inhibitor to said patient if the expression level of said glucose-6-phosphate dehydrogenase is determined by immunohistostaining of the sample to be less than 50% of the staining rate, wherein the skin cancer is selected from the group consisting of Merkel cell carcinoma, malignant melanoma, and cutaneous angiosarcoma, wherein the immune checkpoint inhibitor is an anti-PD-L1 antibody or an anti-PD-1 antibody.
Dependencies are inferred from the claim text.