Interface system and corresponding method

A method performed in an interface system, the interface system comprising a reactor, a reaction-product-separator, and a plurality of valves, the method comprising:

• (a) receiving a liquid containing analytes from a chromatography unit upstream of the interface system;
• (b) guiding the liquid containing analytes through a filter unit to cause one or more contaminants to be removed from the liquid containing analytes, wherein the filter unit is arranged in a liquid transfer line that is downstream of the chromatography unit and upstream of the interface system;
• (c) guiding the liquid containing analytes from the filter unit to the interface system and through the reactor in a reactor forward flow direction, and causing a component comprised by the analytes to react to create a reaction product in the reactor, to thus create a post-reactor liquid comprising the reaction product,
• (d) guiding the post-reactor liquid from the reactor to the reaction-product-separator and through the reaction-product-separator in a separator forward flow direction, and separating the reaction product from the post-reactor liquid, to thus create a post-separator fluid,
• (e) guiding the separated reaction product to an analytical device,
• (f) guiding the post-separator fluid to a waste collector, and
• (g) guiding at least one rinsing liquid through at least one of the reactor or the reaction-product-separator in a reverse flow direction that is opposite of at least one of the reactor forward flow direction or the separator forward flow direction;
• wherein the plurality of valves comprises a first switching valve, a second switching valve, and a closing valve configured to form:
• a first state that guides the liquid containing analytes from the filter unit to the reactor, that guides the post-reactor liquid from the reactor to the reaction-product-separator, that guides the separated reaction product to the analytical device, and that guides the post-separator fluid to the waste collector;
• a second state that guides the at least one rinsing liquid, in the reverse flow direction, through the reactor but not through the reaction-product-separator;
• and
• a third state that guides the at least one rinsing liquid, in the reverse flow direction, through the reactor and the reaction-product-separator;
• wherein the closing valve is arranged between the reaction-product-separator and the waste collector, the closing valve configured to be open to form the second state and closed to form the third state.