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US 12,578,273 B2Granted
Ph-reversible leuco-BODIPY probe for in situ visualization of extracellular vesicles and their secretion from living cells
AssigneeThe Chinese University of Hong Kong
InventorsChung Hang Jonathan Choi, Hanzhuang Liu
Life of this patent
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Abstract
The subject invention pertains to compositions of a probe comprising two pH-reversible forms, including the boron dipyrromethene (BODIPY) fluorescent form and the non-fluorescent leuco-BODIPY form, for use in confocal imaging methods of intracellular vesicles as well as extracellular vesicles that are present in conditioned culture medium and/or secreted by living cells, without inducing severe cytotoxicity.
Claims14
A compound of formula (I) or formula (II):
- wherein the compound of Formula (I) or Formula (II) includes a chromophore having a boron-dipyrromethene (BODIPY) core structure, wherein at least one of X1, X2, X3, and X4 independently represent an electron withdrawing group and Nu is a nucleophile, wherein X1 is a pyridine group (4-pyridyl group) in the meso position of the core structure.
Dependencies are inferred from the claim text.