Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics

A system for screening chemical compounds for their ability to modulate the biological activity of a cell or a component of a cell, comprising:

• an assay device comprising a multiplicity of wells wherein each well is separated from other wells;
• a plurality of beads where a single bead is suitable for disposal in a single well, wherein each bead comprises a plurality of substantially identical bead-bound compounds, wherein said bead-bound compounds are covalently linked to the bead by a cleavable linker such that said compounds are releasable from said bead in a measurable dose dependent manner as part of an assay,
• said beads further comprising a plurality of substantially identical bead-bound DNA barcodes linked to the bead (i) by a cleavable linker or (ii) by a non-cleavable linker, and wherein the DNA barcode identifies the compound, and wherein each bead comprises at least about 10,000 substantially identical DNA barcodes;
• and
• a transfer dispenser comprising cavities aligned over corresponding wells of the assay device to form a closed chamber between each of the cavities and each of the wells, wherein each of the cavities is configured to hold the single bead transferred into each of the corresponding wells.