Genetically modified microorganism for producing 3-hydroxyhexanedioic acid and/or (e)-hex-2-enedioic acid and production method for said chemicals
AssigneeToray Industries, Inc.
InventorsKyohei Isobe, Kenji Kawamura, Katsushige Yamada
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Abstract
A genetically modified microorganism that can produce 3-hydroxyadipic acid and/or α-hydromuconic acid with a high yield; and a method of producing 3-hydroxyadipic acid and/or α-hydromuconic acid using the genetically modified microorganism, are disclosed. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid and/or α-hydromuconic acid, and has an enhanced enzymatic activity to catalyze a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, wherein, in the genetically modified microorganism, a dicarboxylic acid excretion carrier function is deleted or decreased.
Claims8
A genetically modified microorganism having an ability to produce 3-hydroxyadipic acid and/or α-hydromuconic acid, and having an enhanced enzymatic activity to catalyze a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, wherein, in the genetically modified microorganism, a dicarboxylic acid excretion carrier function is deleted or decreased.
Dependencies are inferred from the claim text.