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US 12,577,570 B2Granted
Modified neuraminidase
AssigneeTokushima University
InventorsKohji Itoh, Jun Tsukimoto
Life of this patent
Estimating the term…
Abstract
Provided are a modified-type neuraminidase, a gene encoding the modified-type neuraminidase, a combination of the modified-type neuraminidase and cathepsin A, a combination of the gene encoding the modified-type neuraminidase and a gene encoding cathepsin A, a vector including said genes, and a pharmaceutical composition containing same. The pharmaceutical composition can be used for the therapy of lysosomal storage disease.
Claims20
A modified neuraminidase comprising an amino acid sequence having a sequence identity of at least 90% to the amino acid sequence set forth in SEQ ID NO:
- 1, wherein the amino acid sequence has the following mutations with respect to the amino acid sequence set forth in SEQ ID NO:
- 1:
- (i) W173N and K175S mutations;
- or
- (ii) K358N mutation.
2 more elements
Dependencies are inferred from the claim text.