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US 12,577,536 B2Granted
Method for isolating ureteric bud tip cells
AssigneeKyoto University
InventorsKenji Osafune, Shinichi Mae, Makoto Ryosaka
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Abstract
Provided is a method for isolating a ureteric bud tip cell from cells, a tissue, or an organoid comprising the ureteric bud tip cell, comprising the following steps of contacting the cells, tissue, or organoid comprising the ureteric bud tip cell with a very low density lipoprotein receptor (VLDL-R) binding agent, and isolating the ureteric bud tip cell using the binding agent as an indicator.
Claims8
A method for isolating a ureteric bud tip cell from cells, a tissue, or an organoid comprising the ureteric bud tip cell, comprising the following steps of:
- (1-1) contacting the cells, tissue, or organoid comprising the ureteric bud tip cell with a labelled very low density lipoprotein (VLDL), and
- (1-2) isolating the ureteric bud tip cell using the labelled VLDL as an indicator,
- wherein the cells, tissue, or organoid comprising the ureteric bud tip cell is differentiated from a human induced pluripotent stem cell.
Dependencies are inferred from the claim text.