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US 12,577,522 B2Granted
System and method for screening therapeutic agents
AssigneesCarnegie Mellon University, University of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPhilip LeDuc, Li Wan, Carola Neumann, John Skoko, Jun Yin, Mei Zhang
Life of this patent
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Abstract
A drug screening device is provided. A method of determining optimal drug concentrations and efficacy in a patient using the device are provided. A method of determining effective chemotherapeutic drugs and effective concentrations thereof using the device is provided. Also, a method of determining safety and efficacy of drugs using the device is provided.
Claims15
A device comprising:
- a containment structure comprising a base and one or more walls and configured to hold a hydrogel therein;
- a biocompatible hydrogel contained within the containment structure, the biocompatible hydrogel defining a plurality of wells configured to retain a therapeutic agent, the plurality of wells formed in the hydrogel, and wherein the hydrogel is configured to allow for diffusion of the therapeutic agent thereby forming a concentration gradient of the therapeutic agent within the hydrogel;
- and
- a live, solid tissue sample embedded in the hydrogel and spaced apart from the first well,
- wherein the concentration gradient allows for determination of an effective dose of the therapeutic agent based on a determination of an effect of the therapeutic agent on the tissue sample.
2 more elements
A device comprising:
- a biocompatible hydrogel defining at least a first well configured to retain a therapeutic agent, the at least first well formed in the hydrogel, wherein the hydrogel is configured to allow for diffusion of the therapeutic agent thereby forming a concentration gradient of the therapeutic agent within the hydrogel;
- and
- a live, solid tissue sample embedded in the hydrogel and spaced apart from the first well,
- wherein the concentration gradient allows for determination of an effective dose of the therapeutic agent based on a determination of an effect of the therapeutic agent on the tissue sample.
1 more element
Dependencies are inferred from the claim text.