Compositions and conjugates comprising an interleukin and polypeptides that specifically bind TGF-beta
AssigneesEmory University, Children's Healthcare of Atlanta, Inc.
InventorsJacques Galipeau, Spencer Ng
Life of this patent
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Abstract
This disclosure relates to compositions and conjugates comprising an interleukin, e.g., IL-15 and a polypeptide that specifically binds TGF-beta. Typically the polypeptide that specifically binds TGF-beta is a type II TGF-beta receptor. In certain embodiments, the type II TGF-beta receptor is a human isoform, fragment or variant thereof. Uses for treating or preventing cancer and infectious diseases are contemplated.
Claims7
A conjugate comprising a polypeptide fragment of type II TGF-beta receptor that specifically binds TGF-beta;
- a polypeptide fragment of a sushi domain of the IL-15 receptor alpha chain that specifically binds IL-15;
- and a polypeptide fragment of IL-15, wherein the conjugate has greater than 90% sequence identity to TIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQE VCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECND NIIFSEEYNTSNPDGTGGSSGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLT ECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVIS DLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSL SSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS (SEQ ID NO:
- 21).
A conjugate comprising a polypeptide fragment of type II TGF-beta receptor that specifically binds TGF-beta;
- a polypeptide fragment of a sushi domain of the IL-15 receptor alpha chain that specifically binds IL-15;
- and a polypeptide fragment of IL-15, wherein the conjugate has greater than 90% sequence identity to TIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCNISNCSITSICKPQE VCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECND NIIFSEEYNTSNPDTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNC SITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMC SCSSDECNDIIFSEEYNTSNPDGTGGSSGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFK RKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGS LQNWVNIVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASHDTVE NLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS (SEQ ID NO:
- 27).
Dependencies are inferred from the claim text.