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US 12,577,321 B2Granted
Oligomeric IgG for immunotherapeutics and diagnostics
AssigneeMedicovestor, Inc.
InventorSeah Lim
Life of this patent
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Abstract
This disclosure relates to dimeric immunotherapeutics that comprise an IgG that is crosslinked with a disulfide bond. The IgG may include two heavy chains including a cysteine mutation that forms the disulfide bond. The dimeric immunotherapeutics are formed by increasing the concentration of the IgG such that spontaneous dimerization via the formation of disulfide bonds between the IgG molecules occurs over time.
Claims20
An oligomeric immunotherapeutic, comprising:
- at least two first IgGs that each comprise a first light chain, a first heavy chain, a second light chain, and a second heavy chain, which each have an amino acid sequence numbered according to the EU numbering system;
- the amino acid sequences of the at least two first IgGs are identical;
- the amino acid sequences of the first heavy chain of the at least two first IgGs each include a mutation of a native amino acid to a cysteine;
- the cysteine of the amino acid sequence of the first heavy chain of the at least two first IgGs form a disulfide bond with each other;
- the amino acid sequences of the second heavy chain of the at least two first IgGs each lack the mutation;
- the at least two first IgGs are both chimeric human IgG1s;
- the native amino acid is S444;
- and
- the mutation is S444C.
6 more elements
An oligomeric immunotherapeutic, comprising:
- at least two first IgGs that each comprise a first light chain, a first heavy chain, a second light chain, and a second heavy chain, which each have an amino acid sequence numbered according to the EU numbering system;
- the amino acid sequences of the at least two first IgGs are identical;
- the amino acid sequences of the first heavy chain of the at least two first IgGs each include a mutation of a native amino acid to a cysteine;
- the cysteine of the amino acid sequence of the first heavy chain of the at least two first IgGs form a disulfide bond with each other;
- and
- the amino acid sequences of the second heavy chain of the at least two first IgGs each lack the mutation.
3 more elements
Dependencies are inferred from the claim text.