Anti-TROP2 antibody
AssigneeSystimmune, Inc.
InventorsYi Zhu, Yong Zhang, Shi Zhuo, Muran Ding, Zun Wang
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Abstract
The present disclosure relates to antibodies, in particular monoclonal antibodies of murine, chimeric, and humanized origin, that specifically bind to the human TROP2 protein, and to the amino acid and nucleotide sequences encoding these antibodies. The disclosure also discloses the use of these antibodies as a diagnostic reagent or a drug in the diagnostic and/or therapeutic management of malignancies or any lesion related to the overexpression of the receptor.
Claims19
An anti-TROP2 antibody or its Fv, scFv, Fab, F(ab′)2, Fab′, or scFv-Fc fragment thereof, comprising a heavy chain and a light chain, wherein the heavy chain comprises amino acid sequence SEQ ID NO:
- 13 or 17 and the light chain comprises amino acid sequence SEQ ID NO:
- 14 or 18, or wherein the heavy chain comprises amino acid sequence SEQ ID NO:
- 15 or 19 and the light chain comprises amino acid sequence SEQ ID NO:
- 16 or 20.
An antibody fragment or its derivative having at least one of the following sets of CDRs wherein each set of CDRs comprises an amino acid sequence of SEQ ID NO:
- 4-6, 7-9, or 10-12.
Dependencies are inferred from the claim text.