Anti-CD5 antibody compositions and uses thereof
AssigneeCity of Hope
InventorsHua Yu, Chunyan Zhang
Life of this patent
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Abstract
Provided herein are, inter alia, antibodies (e.g., humanized antibodies, monoclonal antibodies) and antibody compositions (e.g., chimeric antigen receptors, bispecific antibodies) that are capable of binding CD5. The antibodies and antibody compositions provided herein include novel light and heavy chain domain CDRs and framework regions, and bind CD5 with high efficiency and specificity, thereby effectively targeting CD5 expressing cells. The antibodies provided herein may form part of recombinant proteins also referred to herein as antibody compositions (e.g., chimeric antigen receptors or bispecific antibodies) to be used, inter alia, for therapeutic cancer applications.
Claims19
An anti-CD5 antibody comprising a light chain variable domain and a heavy chain variable domain,
- wherein said light chain variable domain comprises:
- a CDR L1 as set forth in SEQ ID NO:1, a CDR L2 as set forth in SEQ ID NO:
- 2 and a CDR L3 as set forth in SEQ ID NO:3;
- and
- wherein said heavy chain variable domain comprises:
- a CDR H1 as set forth in SEQ ID NO:4, a CDR H2 as set forth in SEQ ID NO:
- 5, and a CDR H3 as set forth in SEQ ID NO:6.
A recombinant protein comprising:
- (i) an antibody region comprising:
- (a) a light chain variable domain comprising a CDR L1 as set forth in SEQ ID NO:
- 1, a CDR L2 as set forth in SEQ ID NO:2 and a CDR L3 as set forth in SEQ ID NO:3;
- and
- (b) a heavy chain variable domain a CDR H1 as set forth in SEQ ID NO:4, a CDR H2 as set forth in SEQ ID NO:5, and a CDR H3 as set forth in SEQ ID NO:6;
- and
- (ii) a transmembrane domain.
A recombinant protein comprising:
- (i) a first antibody region capable of binding an effector cell ligand;
- and
- (ii) a second antibody region, comprising:
- (a) a light chain variable domain comprising a CDR L1 as set forth in SEQ ID NO:
- 1, a CDR L2 as set forth in SEQ ID NO:2 and a CDR L3 as set forth in SEQ ID NO:3;
- and
- (b) a heavy chain variable domain a CDR H1 as set forth in SEQ ID NO:4, a CDR H2 as set forth in SEQ ID NO:5, and a CDR H3 as set forth in SEQ ID NO:6.
Dependencies are inferred from the claim text.