Bispecific anti PD1-anti TIM3 antibodies

A method for interfering with Programmed Cell Death 1 protein (PD-1) and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) mediated inhibition in a PD-1 and/or TIM-3 positive cell, the method comprising contacting said cell with an antibody or a functional part, derivative and/or analogue thereof that comprises

• a variable domain that can bind to an extracellular part of PD-1 comprising a heavy chain variable region with a CDR1, CDR2 and CDR3 region that comprises the amino acid sequence of the CDR1, CDR2 and CDR3 of a heavy chain variable region according to any one of MF6076 (SEQ ID NO:
• 43);
• MF6226 (SEQ ID NO:
• 44);
• MF6236 (SEQ ID NO:
• 45);
• MF6256 (SEQ ID NO:
• 46);
• MF6930 (SEQ ID NO:
• 47);
• MF6932 (SEQ ID NO:
• 48);
• MF6935 (SEQ ID NO:
• 49);
• MF6936 (SEQ ID NO:
• 50);
• MF6972 (SEQ ID NO:
• 51);
• MF6974 (SEQ ID NO:
• 52);
• or MF6982 (SEQ ID NO:
• 53);
• and
• a variable domain that can bind to an extracellular part of TIM-3 comprising a heavy chain variable region with a CDR1, CDR2 and CDR3 region that comprises the amino acid sequence of the CDR1, CDR2 and CDR3 of a heavy chain variable region according to any one of MF7676 (SEQ ID NO:
• 54);
• MF7677 (SEQ ID NO:
• 55);
• MF7678 (SEQ ID NO:
• 56);
• or MF7679 (SEQ ID NO:
• 57);
• wherein the variable domains that can bind to an extracellular part of PD-1 and TIM-3 comprise a light chain variable region having the CDR1, CDR2 and CDR3 sequences of the light chain variable region according to SEQ ID NO:
• 26, thereby inhibiting PD-1 and/or TIM-3 mediated activity in said cell.