Neutralizing antibodies to human endothelin
AssigneeFather Flanagan's Boys' Home Business
InventorDominic Cosgrove
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Abstract
This application provides antibodies and functional equivalents thereof which are capable of neutralizing endothelin-1, as well as their use in the treatment of disease conditions associated with endothelin-1 activation, such as Alport syndrome.
Claims23
An antibody or antigen binding fragment thereof capable of specifically binding human endothelin-1, the antibody or antigen binding fragment thereof comprising a heavy chain variable region complementarity determining region (CDR) 1, a heavy chain variable region CDR2, a heavy chain variable region CDR3, a light chain variable region CDR1, a light chain variable region CDR2, and a light chain variable region CDR3 of the monoclonal antibody produced by the hybridoma cell line Nab #7 3G 9A4 deposited under ATCC Patent Deposit Designation PTA-125818.
An antibody or antigen binding fragment thereof capable of specifically binding human endothelin-1, the antibody or antigen binding fragment thereof comprising the heavy chain variable region (VH) and light chain variable region (VL) of the monoclonal antibody produced by the hybridoma cell line Nab #7 3G 9A4 deposited under ATCC Patent Deposit Designation PTA-125818.
The monoclonal antibody produced by hybridoma cell line Nab #7 3G 9A4 deposited under ATCC Patent Deposit Designation PTA-125818, or an antigen binding fragment thereof.
Dependencies are inferred from the claim text.