Surrogate co-receptors for t cells and methods of use
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMichael S. Kuhns, Deepta Bhattacharya, Heather Lynn Bronnimann
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Abstract
Surrogate co-receptors for T cells, including T cells expressing chimeric receptors comprising major histocompatibility molecules grafted onto T cell receptor molecules. The surrogate co-receptors feature a portion of CD8, wherein the Ig domains of CD8 are replaced with Ig domains that confer novel specificities (e.g. antibody Fv fragments specific for a target of interest.) The surrogate co-receptors may be used to help enhance CRMpMHC-CD3 signaling as part of a 5-module receptor system. The present invention also describes Lck fusions.
Claims20
A surrogate co-receptor (SCoR) comprising a first chain comprising:
- a portion of a T-cell co-receptor linked to a C-terminal of a first binding portion, wherein the portion of the T-cell co-receptor comprises at least a portion of a CD8 chain, a portion of a CD4 chain or a combination thereof, wherein the first binding portion is an Ig domain against a particular target expressed on a surface of a target cell.
A surrogate co-receptor (SCoR) comprising a first chain comprising:
- a portion of a T-cell co-receptor linked to a C-terminal of a first binding portion, wherein the portion of the T-cell co-receptor comprises at least a portion of a CD8 chain, a portion of a CD4 chain or a combination thereof, wherein the first binding portion is an Ig domain against a particular target, wherein the portion of the CD8 or the portion of the CD4 chain further comprise a Lck protein fused to or replacing an intracellular domain (ICD).
Dependencies are inferred from the claim text.