Back to results
US 12,577,282 B2Granted
Galectin-1/ galectin-3 chimeras and multivalent proteins
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsGregory Allan Hudalla, Margaret Mary Fettis
Life of this patent
Estimating the term…
Abstract
Described herein are Galectin-1/Galectin-3 multivalent protein complexes and uses thereof. In some aspects, Galectin-1/Galectin-3 multivalent protein complexes are useful to treat inflammatory conditions in a subject.
Claims19
A Galectin-1/Galectin-3 (Gal-1/Gal-3) dimer comprising:
- two monomer polypeptides, wherein each monomer polypeptide comprises:
- a Galectin-1 (Gal-1) polypeptide;
- a Galectin-3 (Gal-3) polypeptide;
- and
- a linker comprising an alpha helix coil, wherein the alpha helix coil comprises the sequence of SEQ ID NO:
- 9, wherein the linker is fused between the Gal-1 polypeptide and the Gal-3 polypeptide,
- wherein the two monomer polypeptides associate with each other via dimerization at the alpha helix coils to form the Gal-1/Gal-3 dimer, wherein one or both of the monomer polypeptides has a sequence that is about 90% to about 100% identical to SEQ ID NO:
- 3.
5 more elements
A Galectin-1/Galectin-3 (Gal-1/Gal-3) polypeptide capable of dimerizing comprising:
- a Galectin-1 (Gal-1) polypeptide;
- a Galectin-3 (Gal-3) polypeptide;
- and
- a linker comprising an alpha helix coil, wherein the alpha helix coil comprises the sequence of SEQ ID NO:
- 9, wherein the linker is fused between the Gal-1 polypeptide and the Gal-3 polypeptide, wherein the Gal-1/Gal-3 polypeptide has a sequence that is about 90% to about 100% identical to SEQ ID NO:
- 3.
3 more elements
A Galectin-1/Galectin-3 (Gal-1/Gal-3) polynucleotide comprising:
- a polynucleotide that encodes a Galectin-1 (Gal-1) polypeptide;
- a polynucleotide that encodes a Galectin-3 (Gal-3) polypeptide;
- and
- a polynucleotide that encodes a linker comprising an alpha helix coil, wherein the alpha helix coil comprises the sequence of SEQ ID NO:
- 9, wherein the polynucleotide that encodes the alpha helix coil is fused in-frame between the polynucleotide that encodes the Gal-1 polypeptide and the polynucleotide that encodes the Gal-3 polypeptide, wherein the Gal-1/Gal-3 polynucleotide encodes a polypeptide having a sequence that is about 90% to about 100% identical to SEQ ID NO:
- 3.
3 more elements
Dependencies are inferred from the claim text.