Influenza virus vaccines and uses thereof
AssigneeJanssen Vaccines & Prevention B.V.
InventorsBoerries Brandenburg, Johannes Petrus Maria Langedijk, Tina Ritschel, Ferdinand Jacobus Milder, Mandy Antonia Catharina Jongeneelen
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Abstract
Provided herein are isolated mutant influenza hemagglutinin polypeptides, methods for providing isolated mutant hemagglutinin polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.
Claims39
An isolated mutant influenza hemagglutinin polypeptide comprising at least two mutations that increase thermal stability of the polypeptide relative to wild-type influenza hemagglutinin, wherein the mutations comprise substitution mutations at:
- a. amino acid positions 227 and/or 238;
- and/or
- b. amino acid positions 384 and/or 476, wherein the amino acid position corresponds to the amino acid position of SEQ ID NO:1.
An isolated nucleic acid encoding a mutant influenza hemagglutinin polypeptide comprising at least two mutations that increase thermal stability of the polypeptide relative to wild-type influenza hemagglutinin, wherein the mutations are substitutions at:
- a. amino acid positions 227 and/or 238;
- and/or
- b. amino acid positions 384 and/or 476;
- wherein the amino acid position corresponds to the amino acid position of SEQ ID NO:1.
Dependencies are inferred from the claim text.