Macrocyclic compound

A compound represented by the following formula (1):

• in the formula (1),
• R1 is —H, C1-6 alkyl, halogeno-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, —C(O)R12, —S(O2)R12, —C(O)NR11R12, —C(O) OR12, or a 3- to 7-membered saturated ring group, R1 may be substituted with the same or different 1 to 3 substituents selected from a group G1;
• the group G1 is a group consisting of —F, hydroxy, cyano, halogeno-C1-6 alkyl, C1-4 alkoxy, phenyl, 5- to 6-membered heteroaryl, and a 3- to 7-membered saturated ring group, the phenyl and 5- to 6-membered heteroaryl included in the group G1 may be substituted with the same or different 1 to 3 substituents selected from a group GAr;
• the group GAr is a group consisting of —F, —Cl, hydroxy, cyano, C1-6 alkyl, halogeno-C1-6 alkyl, and —NH2;
• R11 is —H, C1-6 alkyl, halogeno-C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, halogeno-C1-6 alkoxy-C1-alkyl, or a 3- to 7-membered saturated ring group;
• R12 is C1-6 alkyl, halogeno-C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, halogeno-C1-6 alkoxy-C1-6 alkyl, a 3- to 7-membered saturated ring group, phenyl, or 5- or 6-membered heteroaryl, the phenyl and 5- or 6-membered heteroaryl as R12 may be substituted with the same or different 1 to 3 substituents selected from the group GAr;
• R2 is —H, C1-6 alkyl, halogeno-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, or a 3- to 7-membered saturated ring group;
• R3 is —H, C1-6 alkyl, halogeno-C1-6 alkyl, hydroxy-C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, or a 3- to 7-membered saturated ring group;
• Ar is 6- to 10-membered aryl or 5- to 10-membered heteroaryl, Ar may be substituted with the same or different 1 to 3 substituents selected from the group G2;
• the group G2 is a group consisting of —F, —Cl, hydroxy, cyano, C1-6 alkyl, halogeno-C1-6 alkyl, hydroxy-C1-6 alkyl, RAr1—O—C1-3 alkyl, RAr1—NR13—C1-3 alkyl, —NR13C(O)R14, —C(O)NR13R14, —C(O)NH2, —NR13S(O2)R14, —S(O2) NR13R14, —NH2, —S(O2)NH2, —NR13R 14, and —NHC(O)NHR15;
• RAr1 is —H, C1-6 alkyl, halogeno-C1-6 alkyl, or a 3- to 7-membered saturated ring group, RAr1 may be substituted with the same or different 1 to 3 substituents selected from the group G3;
• the group G3 is a group consisting of —F, hydroxy, C1-3 alkyl, halogeno-C1-3 alkyl, oxo, C1-3 alkoxy, halogeno-C1-3 alkoxy, and a 3- to 7-membered saturated ring group;
• R13 is —H, C1-3 alkyl, halogeno-C1-3 alkyl, C1-3 alkoxy-C1-3 alkyl, halogeno-C1-3 alkoxy-C1-3 alkyl, or a 3- to 7-membered saturated ring group;
• R14 is C1-3 alkyl, halogeno-C1-3 alkyl, C1-3 alkoxy-C1-3 alkyl, halogeno-C1-3 alkoxy-C1-3 alkyl, or a 3- to 7-membered saturated ring group;
• R15 is —H, phenyl, or 5- or 6-membered heteroaryl, R15 may be substituted with the same or different 1 to 3 substituents selected from the group G4;
• the group G4 is a group consisting of halogen, cyano, C1-3 alkyl, and halogeno-C1-3 alkyl;
• X1 is N or CH;
• X2 is NH or O;
• X3 is a group represented by the following formula (1-1):
• the following formula (1-2):
• or
• the following formula (1-3):
• a and b represent direction of bonding:
• R21 and R22 are independently —H, C1-3 alkyl, or halogeno-C1-3 alkyl;
• X4 is a group represented by the following formula (2-1):
• b and c represent direction of bonding;
• in the formula (2-1),
• n is an integer of 1 to 3;
• Y is NR51 or O;
• R31 and R32 are independently —H, C1-3 alkyl, or halogeno-C1-3 alkyl;
• or
• R31 and R32 may combine to form a 3- to 6-membered saturated ring;
• R41 and R42 are independently —H, —F, hydroxy, C1-3 alkyl, halogeno-C1-3 alkyl, C1-3 alkoxy, or halogeno-C1-3 alkoxy;
• or
• R41 and R42 may combine to form a 3- to 6-membered saturated ring;
• R51 is —H, C1-3 alkyl, or halogeno-C1-3 alkyl;
• or
• R51 and R31 may combine to form a 4- to 6-membered saturated ring;
• X4 may be substituted with the same or different 1 to 3 substituents selected from the group G5;
• and
• the group G5 is a group consisting of —F, hydroxy, C1-3 alkyl, halogeno-C1-3 alkyl, C1-3 alkoxy, and halogeno-C1-3alkoxy,
• or a salt thereof.