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US 12,577,257 B2Granted
Heterocyclic compounds
AssigneeHoffmann-La Roche Inc.
InventorsBernd Kuhn, Uwe Grether, Benoit Hornsperger, Hans Richter, Carsten Kroll, Katrin Groebke Zbinden, Fionn O'Hara, Didier Rombach, Marius Daniel Rinaldo Lutz
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Abstract
The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Claims25
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- (i) X is C—R5;
- L is a covalent bond, —(CH2)n—N(C1-6-alkyl)-, —(CH2)n—NH—, —N(C1-6-alkyl)-(CH2)p—, —NH—(CH2)p—, —(CH2)—O—, —O—(CH2)p—, —SO2—N(C1-6-alkyl)-, —SO2—NH—, —N(C1-6-alkyl)-SO2—, —NH—SO2—, carbonyl, —(CH2)n—, —CHR6—, —CF2—(CH2)n—, —(CH2)p—CF2—, —(CH2)n—S—, —S—(CH2)p—, —SO2—, —C(O)—NH—, —C(O)—N(C1-6-alkyl)-, —NH—C(O)— or —N(C1-6-alkyl)-C(O)—;
- and
- A is:
- (i) C6-14-aryl substituted with R7, R8 and R9;
- or
- (ii) 5-14 membered heteroaryl substituted with R10, R11 and R12;
- or
- (ii) X is N;
- L is a covalent bond, —(CH2)n,-, —CHR6—, —SO2—, carbonyl, —N(C1-6-alkyl)-(CH2)p—, —NH—(CH2)p—, —O—(CH2)p—, —CF2—CH2—, —N(C1-6-alkyl)-SO2—, —NH—SO2—, —NH—C(O)— or —N(C1-6-alkyl)-C(O)—;
- and
- A is:
- (i) C6-14-aryl substituted with R7, R8 and R9;
- or
- (ii) 5-14 membered heteroaryl substituted with R10, R11 and R12;
- or
- (iii) X is N;
- L is C1-6-alkoxycarbonyl, C6-14-aryloxycarbonyl or 5-14 membered heteroaryloxycarbonyl;
- and
- A is absent;
- B is a bicyclic spirocycle;
- R1, R2, R3, R4 and R5 are independently hydrogen, halogen, hydroxy, C1-6-alkyl or halo-C1-6-alkyl;
- R6 is C6-14-aryl or 5-14 membered heteroaryl;
- R7, R8, R9, R10, R11 and R12 are each at each occurrence independently hydrogen, hydroxy, C1-6-alkyl, halo-C1-6-alkyl, halogen, C1-6-alkoxy, halo-C1-6-alkoxy, SF5, C1-6-alkylsulfonyl, cyano or a group
- C is 5-14 membered heteroaryl, 3-14 membered heterocyclyl or C3-10-cycloalkyl;
- RC1, RC2 and RC3 are each independently hydrogen, C1-6-alkyl, halo-C1-6-alkyl, oxo, halogen, hydroxy, C1-6-alkoxy or halo-C1-6-alkoxy;
- each occurrence of n is independently 0, 1, 2 or 3;
- and
- each occurrence of p is independently 1, 2 or 3.
27 more elements
Dependencies are inferred from the claim text.