Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors

A compound or a pharmaceutically acceptable salt thereof having the Formula IVc:

• wherein,
• M is independently sulfur(S) or oxygen (O);
• R2 is selected from H, halogen, alkyl, alkenyl, alkynyl, carbocycle, aryl, heterocycle, heteroaryl, formyl, nitro, cyano, amino, carboxylic acid, carboxylic ester, carboxyl amide, reverse carboxyamide, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted carbocycle, substituted aryl, substituted heterocycle, substituted heteroaryl, phosphonic acid, phosphinic acid, phosphoramidate, phosphonic ester, phosphinic ester, ketone, substituted ketone, hydroxamic acid, N-substituted hydroxamic acid, O-substituted hydroxamate, N-substituted hydroxamate, sulfoxide, substituted sulfoxide, sulfone, substituted sulfone, sulfonic acid, sulfonic ester, sulfonamide, N-substituted sulfonamide, N,N-disubstituted sulfonamide, boronic acid, boronic ester, azo, substituted azo, azido, nitroso, imino, substituted imino, oxime, substituted oxime, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, thioether, substituted thioether, carbamate, or substituted carbamate;
• R4 is selected from R2;
• G6 is selected from sulfur(S) or oxygen (O);
• X7=C, N
• X8=O, S
• X9=O, S
• G27=null (when X7=N), H, F, Cl, Br, CF3, CH3, CH2CH3, CH(CH3)2
• G28=H, F, Cl, Br, CF3, CH3, CH2CH3, CH(CH3)2
• G29=H, F, Cl, Br, CF3, CH3, CH2CH3, CH(CH3)2
• G30=H, CF3, CH2CH3, CH(CH3)2, CF3, NH2, NHCH3, N(CH3)2, G31
• G31=alkyl,
• where *=point of attachment