Drug for the treatment of diseases caused by bacteria
AssigneesGeorgy Viktorovich Tets, Victor Veniaminovich Tets
InventorsGeorgy Viktorovich Tets, Viktor Veniaminovich Tets, Konstantin Andreevich Krasnov
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Abstract
The invention relates to chemistry and pharmacology, specifically to a synthetic biologically active substance—7,9-dibromo-2,4-dioxo-1,2,3,4-tetrahydrochromeno[2,3-d]-pyrimidinium-10 acetate or succinate formula 1:1 Where X−═CH3COO− or HOOCCH2CH2COO−, as well as its tautomeric, hydrated forms, solvate, complex compounds, adducts and salt forms, possessing antimicrobial activity, and the ability to penetrate bacterial biofilms. The compound is intended for the treatment of bacterial infections of the oropharynx, skin, and mucous membranes, urinary system, implants, respiratory system, gastrointestinal tract. osteomyelitis, sepsis, nosocomial and wound infections.
Claims13
A 7,9-dibromo-2,4-dioxo-1,2,3,4-tetrahydrochromeno[2,3-d]-pyrimidinium-10 compound of formula 1:
- where X− is selected from the group consisting of ═CH3COO− and HOOCCH2CH2COO−;
- or tautomers, hydrated forms, solvates, or salt forms thereof.
A method for treating bacterial infections in a subject by administering a pharmaceutical composition comprising (i) a 7,9-dibromo-2,4-dioxo-1,2,3,4-tetrahydrochromeno[2,3-d]-pyrimidinium-10 compound of Formula 1:
- where X− is selected from the group consisting of ═CH3COO− and HOOCCH2CH2COO−;
- or
- or tautomers, hydrated forms, solvates, or salt forms thereof;
- and (ii) a pharmaceutically acceptable carrier or diluent;
- wherein
- the bacterial infection is caused by at least one of firmicutes bacteria, Staphylococcus aureus, Haemophilus influenzae, Neisseria meningitides, Ureaplasma urealyticum, or Escherichia coli.
Dependencies are inferred from the claim text.