Modulators of the sigma-2 receptor and their method of use

A compound having formula (XVII):

• or
• pharmaceutically acceptable salt thereof, wherein:
• R3 is selected from a group consisting of a benzene ring that is optionally substituted with 0 to 3 R4 groups that are not hydrogen, a 4-pyridine ring that is optionally substituted with 0 to 2 R5 groups that are not hydrogen, a 3-pyridine ring that is optionally substituted with 0 to 2 R5 groups that are not hydrogen, and a 2-pyridine ring that is optionally substituted with 0 to 2 R5 groups that are not hydrogen;
• R4 is at each occurrence independently selected from the group consisting of hydrogen, OH, NO2, halogen, CN, C1-6 linear alkyl, C3-7 branched alkyl, C3-7 cycloalkyl, C1-6 linear alkoxy, C3-7 branched alkoxy, C3-7 cycloalkoxy, C1-6 linear haloalkyl, C3-7 branched haloalkyl, C1-6 linear haloalkoxy, heterocyclyl, —S(C1-6 linear alkyl), S(C3-7 branched alkyl), —S(C3-7 cycloalkyl), —SO2(C1-6 linear alkyl), SO2(C3-7 branched alkyl), —SO2(C3-7 cycloalkyl), COR6, CO2R7, CONR8aR8b, SO2NR8aR8b, NR9aR9b, NR9aCOR10, NR9aSO2R11, and NR9aSO2NR12aR12b;
• the terms R4a, R4b, R4c, R4d, and R4e may be used to designate individual R4 groups on a benzene ring;
• R5 is at each occurrence independently selected from the group consisting of hydrogen, OH, NO2, halogen, CN, C1-6 linear alkyl, C3-7 branched alkyl, C3-7 cycloalkyl, C1-6 linear alkoxy, C3-7 branched alkoxy, C3-7 cycloalkoxy, C1-6 linear haloalkyl, C3-7 branched haloalkyl, C1-6 linear haloalkoxy, heterocyclyl, —S(C1-6 linear alkyl), S(C3-7 branched alkyl), —S(C3-7 cycloalkyl), COR6, CO2R7, CONR8aR8b, SO2NR8aR8b, NR9aR9b, NR9aCOR10, NR9aSO2R11, and NR9aSO2NR12aR12b;
• the terms R5a, R5b, R5c, and R5d may be used to designate individual R5 groups on a pyridine ring;
• R6 is at each occurrence independently selected from the group consisting of hydrogen, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R7 is at each occurrence independently selected from the group consisting of C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R8a is at each occurrence independently selected from the group consisting of H, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R8b is at each occurrence independently selected from the group consisting of H, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R9a is at each occurrence independently selected from the group consisting of H, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R9b is at each occurrence independently selected from the group consisting of H, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R9a and R9b may be taken together with the atom to which they are bound to form a ring having from 3 to 7 ring atoms optionally containing an oxygen;
• R10 is at each occurrence independently selected from the group consisting of H, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R11 is at each occurrence independently selected from the group consisting of C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R12a is at each occurrence independently selected from the group consisting of hydrogen, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• R12b is at each occurrence independently selected from the group consisting of hydrogen, C1-6 linear alkyl, C3-7 branched alkyl, and C3-7 cycloalkyl;
• and
• n is 1, 2, or 3.