1,2,4-triazolone derivative as DHODH inhibitor, and preparation method therefor and use thereof
AssigneeWigen Biomedicine Technology (Shanghai) Co., Ltd.
InventorsYuli Xie, Houxing Fan, Lihui Qian
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Abstract
The present invention relates to a 1,2,4-triazolone derivative as a DHODH inhibitor, a preparation method therefor and use thereof. Specifically, the present invention relates to a compound of general formula (1), a preparation method therefor, and use of the compound of general formula (1) and an isomer, a crystalline form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof as a DHODH inhibitor in the treatment of DHODH-related diseases.
Claims6
A compound of general formula (1) or an isomer, a crystalline form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof:
- wherein in general formula (1):
- n is 0, 1 or 2;
- X is CH or N;
- R1 is aryl or heteroaryl, wherein the aryl and heteroaryl may be substituted with one or more of the following groups:
- halogen, NH2, C1-C3 alkyl, C1-C3 alkoxy or halogenated C1-C3 alkyl;
- R2 is H or F;
- R3 is C1-C3 alkyl;
- R4 is C1-C6 alkyl, C3-C8 cycloalkyl or halogenated C1-C6 alkyl.
Dependencies are inferred from the claim text.