Pyrrolopyridine and imidazopyridine antiviral compounds

A compound of formula (IC) or a stereoisomer, or tautomer thereof,

• wherein,
• R1 is selected from the group consisting of
• wherein the wavy line () indicates the point of attachment to the methylene linker of the main formula (IC);
• t is an integer selected from 0, 1, 2, 3 and 4;
• r is an integer selected from 0, 1, 2, 3 and 4;
• m is an integer selected from 0, 1, 2, 3 and 4;
• W is selected from the group consisting of NR10, S and O;
• Q is selected from the group consisting of CR11 and N;
• Y is selected from the group consisting of N and CR12;
• V is selected from the group consisting of NR13, S and O;
• R2 is selected from the group consisting of biphenylenyl, 1-naphthalenyl, 2-naphthalenyl, 5-tetralinyl, 6-tetralinyl, 1-azulenyl, 2-azulenyl, 3-azulenyl, 4-azulenyl, 5-azulenyl, 6-azulenyl, 7-azulenyl, 8-azulenyl, 4-indenyl, 5-indenyl, 6-indenyl, 7-indenyl, 4-indanyl, 5-indanyl, 5-tetrahydronaphthyl, 6-tetrahydronaphthyl, 7-tetrahydronaphthyl, 8-tetrahydronaphthyl, 1,2,3,4-tetrahydronaphthyl, 1,4-dihydronaphthyl, 1-pyrenyl, 2-pyrenyl, 3-pyrenyl, 4-pyrenyl, 5-pyrenyl pyrazolyl and pyridyl;
• wherein said biphenylenyl, 1-naphthalenyl, 2-naphthalenyl, 5-tetralinyl, 6-tetralinyl, 1-azulenyl, 2-azulenyl, 3-azulenyl, 4-azulenyl, 5-azulenyl, 6-azulenyl, 7-azulenyl, 8-azulenyl, 4-indenyl, 5-indenyl, 6-indenyl, 7-indenyl, 4-indanyl, 5-indanyl, 5-tetrahydronaphthyl, 6-tetrahydronaphthyl, 7-tetrahydronaphthyl, 8-tetrahydronaphthyl, 1,2,3,4-tetrahydronaphthyl, 1,4-dihydronaphthyl, 1-pyrenyl, 2-pyrenyl, 3-pyrenyl, 4-pyrenyl, 5-pyrenyl, pyrazolyl or pyridyl are optionally substituted with one or more Z1;
• each R3 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• R4 is selected from the group consisting of hydrogen, halo, C1-6alkyl, aryl, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, pyrazolyl, pyridyl and thiophenyl;
• wherein said aryl, pyrazolyl, pyridyl, or thiophenyl are optionally substituted with one or more Z2;
• R5 is selected from the group consisting of hydrogen, halo, C1-6alkyl, aryl, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, pyrazolyl, pyridyl and thiophenyl;
• wherein said aryl, pyrazolyl, pyridyl, or thiophenyl are optionally substituted with one or more Z3;
• R6 is selected from the group consisting of hydrogen, halo, C1-6alkyl, aryl, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, pyrazolyl, pyridyl and thiophenyl;
• wherein said aryl, pyrazolyl, pyridyl, or thiophenyl are optionally substituted with one or more Z4;
• R7 is selected from the group consisting of hydrogen, halo, C1-6alkyl, aryl, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, pyrazolyl, pyridyl and thiophenyl;
• wherein said aryl, pyrazolyl, pyridyl, or thiophenyl are optionally substituted with one or more Z5;
• each R8 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• each R9 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• R10 is selected from the group consisting of hydrogen, C1-6alkyl and C3-8cycloalkyl;
• R11 is selected from the group consisting of hydrogen, C1-6alkyl and C3-8cycloalkyl;
• R12 is selected from the group consisting of hydrogen, C1-6alkyl and C3-8cycloalkyl;
• R13 is selected from the group consisting of hydrogen, C1-6alkyl and C3-8cycloalkyl;
• each Z1 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• each Z2 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• each Z3 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• each Z4 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• each Z5 is independently selected from the group consisting of halo, trifluoromethyl, difluoromethyl, C1-6alkoxy, trifluoromethoxy, difluoromethoxy, hydroxyl, C1-6alkyl, —CH2OH, amino, —N(CH3)2, —CH2N(CH3)2, —O(CH2)2OH, —O(CH2)2OCH3, cyano, nitro and —COOH;
• or a solvate, hydrate, salt or prodrug thereof.