Polycyclic pyridopyrazine derivative
AssigneeShionogi & Co., Ltd.
InventorsYutaka Tomida, Takashi Kawasuji
Life of this patent
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Abstract
The present invention provides a compound represented by the following Formula (I): wherein ring A is a C5-C7 non-aromatic carbocycle or a 5- to 7-membered non-aromatic heterocycle; ring B is a benzene ring or the like; Q is —NHC(O)— or a 5-membered aromatic heterocycle; R1 is each independently halogen or the like; R2a and R2b are each independently hydrogen, alkyl, or haloalkyl; R3 is alkyl or the like; R4 and R5 are each independently hydrogen or the like; R6 is each independently halogen, alkyl, haloalkyl, alkyloxy, haloalkyloxy, or alkyloxyalkyl; n is an integer of 1 to 3; and m is an integer of 0 to 3.
Claims14
A compound represented by the following Formula:
- wherein
- ring A is a C5-C7 non-aromatic carbocycle, which may be further fused with a phenyl ring, a 3- to 7-membered non-aromatic carbocycle, or a 3- to 7-membered non-aromatic heterocycle, and which may form a spiro ring of a 3- to 7-membered non-aromatic carbocycle and a 3- to 7-membered non-aromatic heterocycle;
- ring B is a phenyl ring or a pyridinyl ring;
- Q is of the following rings, wherein the left bond binds to CR2aR2b,
- R1 is each independently halogen, C1-4alkyl, haloC1-4alkyl, C1-4alkyloxy, cyano, or haloC1-4alkyloxy;
- R2a and R2b are each independently hydrogen, C1-4alkyl, or haloC1-4alkyl;
- R3 is C1-4alkyl or haloC1-4alkyl;
- R4 and R5 are each independently hydrogen or C1-4alkyl;
- R6 is each independently halogen, C1-4alkyl, haloC1-4alkyl, C1-4alkyloxy, haloC1-4alkyloxy, or C1-4alkyloxyC1-4alkyl;
- or
- two R6s bonded to a non-adjacent atom may be taken together with each other to form a C1-C3 bridge which may have an intervening heteroatom;
- n is an integer of 1 to 3;
- and
- m is an integer of 0 to 3;
- wherein non-aromatic heterocycle means non-aromatic heterocycle containing 1 or 2 heteroatoms selected from the group consisting of O, S and N,
- or a pharmaceutically acceptable salt thereof.
A compound represented by Formula (IA):
- wherein
- ring A is a C5-C6 non-aromatic carbocycle;
- ring B is a phenyl ring or a pyridinyl ring;
- Q is one of the following rings, wherein the left bond binds to CR2aR2b,
- R1 is each independently halogen, C1-4alkyl, haloC1-4alkyl, C1-4alkyloxy, cyano, or haloC1-4alkyloxy;
- R2a and R2b are each independently hydrogen, C1-4alkyl, or haloC1-4alkyl;
- R3 is C1-4alkyl or haloC1-4alkyl;
- R6 is each independently halogen C1-4alkyl, haloC1-4alkyl, C1-4alkyloxy, or haloC1-4alkyloxy;
- or
- two R6s bonded to a non-adjacent atom may be taken together with each other to form a C1-C3 bridge;
- n is an integer of 1 to 3;
- and
- m is an integer of 0 to 2;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.