Antiviral heteroaryl ketone derivatives

A compound of Formula I

• or a pharmaceutically acceptable salt thereof;
• wherein
• A is S or O;
• Z1, Z2, Z3 and Z4 are each independently CR3 or N;
• R1 is selected from the group consisting of C1-C6 alkyl, R1bNH—C1-C6 alkyl-, C1-C6 alkoxy, (C1-C6 alkoxy)-C1-C6 alkyl, C2-C6 alkynyl, C3-C6 alkynyloxy, C3-C12 cycloalkyl optionally fused with a 5- to 6-membered heteroaryl or phenyl, (C3-C12 cycloalkyl)-C1-C6 alkyl, C3-C12 cycloalkoxy, (C3-C12 cycloalkoxy)-C1-C6 alkyl, 4- to 12-membered heterocycloalkyl which is optionally fused with a 5- to 6-membered heteroaryl or phenyl and wherein said heterocycloalkyl comprises one to four heteroatoms independently selected from N, O and S(O)n, (4- to 12-membered heterocycloalkyl)-C1-C6 alkyl wherein said heterocycloalkyl moiety comprises one to four heteroatoms independently selected from N, O and S(O)n, C6-C10 aryl optionally fused with a C4-C6 cycloalkyl or a 4- to 7-membered heterocycloalkyl, (C6-C10 aryl)-C1-C6 alkyl, 5- to 10-membered heteroaryl comprising one to five heteroatoms independently selected from N, O and S, (5- to 10-membered heteroaryl)-C1-C6 alkyl wherein the heteroaryl moiety comprises one to five heteroatoms independently selected from N, O and S, (5- to 10-membered heteroaryloxy)-C1-C6 alkyl wherein the heteroaryl moiety comprises one to five heteroatoms independently selected from N, O and S, (5- to 6-membered heteroaryl)-(5- to 6-membered heteroaryl)- wherein each heteroaryl moiety comprises one to four heteroatoms independently selected from N, O and S, (4- to 7-membered heterocycloalkyl)-(5- to 6-membered heteroaryl)- wherein the heterocycloalkyl moiety comprises one to three heteroatoms independently selected from N, O and S(O)n and the heteroaryl moiety comprises one to four heteroatoms independently selected from N, O and S, and (5- to 6-membered heteroaryl)-(4- to 7-membered heterocycloalkyl)- wherein the heterocycloalkyl moiety comprises one to three heteroatoms independently selected from N, O and S(O)n and the heteroaryl moiety comprises one to four heteroatoms independently selected from N, O and S;
• wherein each R1 group is optionally substituted with one to five R1a;
• R1a at each occurrence is independently selected from the group consisting of oxo, halo, hydroxy, cyano, phenyl, amino, (C1-C3 alkyl)amino, di(C1-C3 alkyl)amino, C1-C6 alkyl optionally substituted with one to five fluoro, C1-C6 alkoxy optionally substituted with one to five fluoro, (C1-C3 alkoxy)-C1-C3 alkyl optionally substituted with one to five fluoro, C3-C6 cycloalkyl optionally substituted with one to three substituents independently selected from fluoro and C1-C3 alkyl, C3-C6 cycloalkyl-C1-C6 alkyl, phenyl, phenyl-C1-C6 alkyl, (C1-C6 alkyl)-C(O)— and (C1-C6 alkyl)-S(O)n—;
• R1b is selected from the group consisting of C1-C6 alkyl-C(O)—, C3-C6 cycloalkyl-C(O)—, C1-C6 alkyl-OC(O)—, C3-C6 cycloalkyl-OC(O)—, (C1-C6 alkyl)2N—C(O)—, (C1-C6 alkyl)2N—(C1-C6 alkyl)-C(O)—, (C1-C6 alkyl)-S(O)2—, (C3-C6 cycloalkyl)-S(O)2—, (4- to 7-membered heterocycloalkyl)-OC(O)— wherein the heterocycloalkyl moiety comprises one to three heteroatoms independently selected from N, O and S(O)n, and 5- to 6-membered heteroaryl comprising one to three heteroatoms independently selected from N, O and S;
• wherein each R1b group is optionally substituted with one to five fluoro or with one to two C1-C3 alkyl;
• R2 at each occurrence is independently selected from the group consisting of fluoro, C1-C6 alkyl optionally substituted with one to three fluoro, and C1-C6 alkoxy optionally substituted with one to three fluoro;
• or two R2 groups when attached to adjacent carbons and taken together with the carbons to which they are attached are a fused C3-C6 cycloalkyl which is optionally substituted with one to four R2a;
• or two R2 groups when attached to the same carbon and taken together with the carbon to which they are attached are a spiro C3-C6 cycloalkyl which is optionally substituted with one to four R2a;
• R2a at each occurrence is independently selected from fluoro, C1-C3 alkyl optionally substituted with one to five fluoro and C1-C8alkoxy optionally substituted with one to five fluoro;
• R3 at each occurrence is independently selected from hydrogen, halo, cyano, C1-C6 alkyl optionally substituted with one to five fluoro, C1-C6 alkoxy optionally substituted with one to five fluoro, and (C1-C6 alkyl)-SO2—;
• m is 1 or 2;
• n at each occurrence is independently selected from 0, 1 and 2;
• and
• p is 0, 1, 2, 3 or 4.