Processes for preparation of Tezacaftor

A process for preparation of tezacaftor of Formula I,

• comprising:
• a) reacting a compound of Formula II with an alkyne of Formula III to obtain a compound of Formula IV,
• wherein “X” represents a suitable leaving group and “P” represents hydrogen or a suitable hydroxyl protecting group;
• b) treating the compound of Formula IV with a compound of Formula V to obtain a compound of formula VI,
• wherein “P” represents hydrogen or a suitable hydroxyl protecting group, “R” represents an oxygen atom or a suitable leaving group and dotted line represents a single bond or a double bond, and “R1” and “R2” may be same or different and represents a hydrogen or an alcoholic protecting group or “R1” and “R2” are taken together to form a diol protecting group;
• c) cyclizing the compound of Formula VI to obtain a compound of Formula VII followed by reduction with a suitable reducing agent to obtain an amine compound of Formula VIII or a salt thereof;
• or, reducing the compound of Formula VI with a suitable reducing agent to obtain a compound of Formula VII′ followed by cyclization to obtain an amine compound of Formula VIII or a salt thereof,
• wherein “P”, “R1”, and “R2” are defined as above;
• d) coupling the amine compound of formula VIII or a salt thereof with an acid compound of Formula IX or a reactive derivative thereof to obtain a compound of Formula X,
• wherein “P” “R1” and “R2” are defined as above;
• and
• e) optionally deprotecting the compound of Formula X with a suitable deprotecting agent to obtain the tezacaftor of Formula I.