Dihydrocyclopenta-isoquinoline-sulfonamide derivatives compounds

A compound of formula (I) or a pharmaceutically acceptable salt thereof:

• Wherein:
• X, Y independently represent C or N;
• V, W independently represent C or O;
• If either V or W represent O then Y represents C;
• If Y represents N then R1′ is absent;
• If V represents O then R2 is absent;
• If W represents O then R7 is absent;
• R1 represents:
• Hydrogen;
• or
• C(O)NH—C1-6-alkyl;
• or
• C(O)NH-heteroaryl;
• or
• heteroaryl optionally substituted with one or more (i) oxo, (ii) hydroxy, (iii) amino, (iv) C(O)NH2, (v) C(O)O—C1-6-alkyl, (vi) heteroaryl, (vii) NH—C1-6-alkyl, (viii) NH—C1-6-alkyl-C3-6-cycloalkyl or (ix) NH-heteroaryl optionally substituted with one or more R1a;
• or
• C1-6-alkyl-C(O)—C1-6-alkylamino;
• or
• C1-6-alkyl-heteroaryl;
• or
• C(O)—C1-6-alkyl-heteroaryl;
• or
• NHC(O)-heteroaryl optionally substituted with one or more R1a;
• or
• NH—C3-8-cycloalkyl optionally substituted with one or more R1a;
• or
• NH—C3-8-heterocycloalkyl optionally substituted with one or more R1a;
• or
• NHC(O)—C1-6-alkyl optionally substituted with one or more-aryl;
• aryl or heteroaryl;
• or
• NHC(O)—NH—C1-6-alkyl;
• or
• NHC(O)O—C1-6-alkyl;
• or
• NH-aryl optionally substituted with one or more (i) C1-6-alkyl, (ii) C(O)—C1-6-alkyl, or (iii) heteroaryl optionally substituted with one or more C1-6-alkyl;
• or
• SO2-C1-6-alkyl;
• or
• SO2—NH—C1-6-alkyl;
• or
• NH—SO2-C1-6-alkyl;
• or
• NHC(O)—C(O)-heteroaryl optionally substituted with one or more halogen or C1-6-alkyl;
• or
• —NH-Heteroaryl substituted with one or more:
• (i) Hydrogen, (ii) R1b, (iii) hydroxy, (iv) halogen, (v) oxo, (vi) C1-6-alkyl, (vii) C1-6-alkoxy, (viii) C1-6-hydroxyalkyl, (ix) C1-6-haloalkyl, (x) C1-6-alkyl-C(O)OH, (xi) C(O)NH2, (xii) SO2NH2, (xiii) S(O)—C1-6-alkyl, (xiv) SO2-C1-6-alkyl, (xv) SO2NHC(O)—C1-6-alkyl, (xvi) SO2-C1-6-alkylamino, (xvi) S(O)(NH)—C1-6-alkyl, (xviii) C1-6-alkyl-C3-8-cycloalkyl, (xix) C3-8-cycloalkyl-C1-6-alkyl, (xx) C1-6-alkoxy-C3-8-cycloalkyl, (xxi) C3-8-cycloalkyl-C1-6-alkoxy, (xxii) C1-6-alkylamino-C3-8-cycloalkyl, (xxiii) C3-8-cycloalkyl-C1-6-alkylamino, (xxiv) C(O)OH, (xxv) C(O)O—C1-6-alkyl, (xxvi) C(O)NH—C1-6-alkyl, (xxvii) NHC(O)—C1-6-alkyl, (xxviii) cyano, (xxix) C3-8-heterocycloalkyl optionally substituted with one or more hydroxy, oxo, C1-6-alkyl or cyano, (xxx) heterocycloalkyloxy optionally substituted with one or more hydroxy, oxo, C1-6-alkyl, C1-6-alkoxy, C3-8-cycloalkyl-C1-6-alkoxy, C(O)NH—C1-6-alkyl or NHSO2-C1-6-alkyl, (xxxi) heteroaryloxy optionally substituted with one or more hydroxy, oxo, C1-6-alkyl or C1-6-alkoxy, (xxxii) heteroarylamino optionally substituted with one or more hydroxy, oxo, C1-6-alkyl or C1-6-alkoxy, or (xxxiii) SO2-heteroaryl optionally substituted with one or more C1-3-alkyl or oxo;
• R1a represents a group selected from the group consisting of:
• (i) Hydrogen, (ii) Halogen, (iii) hydroxy, (iv) oxo, (v) amino, (vi) C1-6-alkyl, (vii) C1-6-alkoxy, (viii) C(O)O—C1-6-alkyl, (ix) C1-6-alkylamino, (x) cyano, (xi) C1-6-haloalkyl, (xii) C1-6-haloalkoxy, (xiii) C(O)OH, and (xiv) C3-8-cycloalkyl;
• R1b represents a group selected from the group consisting of:
• Heteroaryl optionally substituted with one or more (i) halogen, (ii) hydroxy, (iii) oxo, (iv) C1-6-alkyl, (v) C1-6-alkanediyl-C(O)OH, (vi) C(O)NH2, (vii) carbamoyl, (viii) C(O)O—C1-6-alkyl, (ix) S(O) NH—C1-6-alkyl, (x) C3-8-cycloalkyl, (xi) heteroarylamino, (xii) C1-6-alkoxy, (xiii) cyano, (xiv) C1-6-haloalkyl, (xv) C1-6-haloalkoxy or (xvi) C(O)OH;
• R1′ represents:
• hydrogen;
• C1-3-alkyl;
• or C1-3-hydroxyalkyl;
• R2 represents a group selected from the group consisting of:
• Hydrogen;
• C1-3-hydroxyalkyl;
• NHC(O)NH—C1-6-alkyl;
• and hydroxy;
• R1′ and R2 can form together a cyclopropyl ring incorporating V and Y;
• R1 and R1′ can form together a heterocycloalkyl ring optionally substituted with one or more oxo, halogen or C1-6-alkyl;
• R3 represents a group selected from the group consisting of:
• C1-6-alkyl optionally substituted with one or more R3a groups;
• C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R3a groups;
• C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R3a groups;
• C3-6-heterocycloalkyl optionally substituted with one or more R3a groups;
• and
• C3-6-cycloalkyl optionally substituted with one or more R3a groups;
• R3a represents a group selected from the group consisting of hydrogen;
• Halogen;
• C1-2-alkyl;
• hydroxy;
• and C1-2-alkoxy;
• R4 represents:
• C3-6-cycloalkyl optionally substituted with one or more R4a group;
• or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4a group;
• or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4a group;
• R4a represents a group selected from the group consisting of hydroxy;
• Halogen;
• and C1-2-alkyl;
• R5 represents a group selected from the group consisting of:
• Hydrogen;
• hydroxy;
• Halogen;
• C1-3-alkyl optionally substituted with one or more halogen;
• and C1-3-alkoxy;
• R6 represents a group selected from the group consisting of:
• Hydrogen;
• halogen;
• amino;
• NHC(O) C1-6-alkyl;
• C1-3-alkyl optionally substituted with one or more halogen;
• and C1-3-alkoxy;
• R7 represents a group selected from the group consisting of:
• Hydrogen;
• NHC(O)NH—C1-6-alkyl;
• Halogen;
• and hydroxy;
• R1′ and R7 can form together a cyclopropyl ring incorporating W and Y;
• and
• R8 represents hydrogen;
• halogen;
• hydroxy;
• C1-3 alkyl;
• or cyclopropyl.