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US 12,577,225 B2Granted
Nuclear transport modulators and uses thereof
AssigneeKaryopharm Therapeutics Inc.
InventorsErkan Baloglu, Sharon Shacham, Dilara McCauley, Trinayan Kashyap, William Senapedis, Yosef Landesman, Gali Golan, Ori Kalid, Sharon Shechter
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Abstract
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
Claims17
A pharmaceutical composition comprising a compound represented by structural formula IV:
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is selected from optionally substituted heteroaryl and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.