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US 12,577,207 B2Granted
Indazole derivatives as cannabinoid receptor partial agonists
AssigneeResearch Triangle Institute
InventorsGeorge Amato, Rangan Maitra, Scott P. Runyon
Life of this patent
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Abstract
The present disclosure includes peripheral partial agonists of one or more CB receptors, including modulation of CB1, both with and without CB2 selectivity. The compounds of the present disclosure may be useful in the treatment of diseases and disorders mediated by a CB-signaling pathway, including but not limited to pain, gastrointestinal disorders, metabolic disorders, and liver disorders, such as alcoholic steatohepatitis or nonalcoholic steatohepatitis (NASH).
Claims10
A compound of Formula (I):
- wherein
- R1 is unsubstituted or substituted C1-10 alkyl, C1-10 haloalkyl, (CH2)n-cycloalkyl, (CH2)n-heterocyclyl, (CH2)n-aryl, or (CH2)n-heteroaryl;
- n is 1, 2, or 3;
- X is CH or N;
- Y is CH(CH3) or C(CH3)2;
- V is divalent aryl, heteroaryl, cycloalkyl, heterocyclyl, C2-3 alkyl, or C2-3 alkenyl;
- Z is H, F, Cl, CF3, Me, CN, OMe, OCF3, or OCHF2;
- R2 is
- (i) (CH2)pC(O)NHRa;
- (ii) NHC(O)Rb;
- (iii) NRcC(O)NHRa;
- or
- (iv) NH(C═NR)NHRa;
- p is 0, 1, or 2;
- Ra is H, C1-4 alkyl, C3-6 cycloalkyl, heterocyclyl, aryl, or heteroaryl;
- Rb is C1-4 alkyl, C3-6 cycloalkyl, heterocyclyl, aryl, or heteroaryl;
- Rc is H or C1-4 alkyl;
- and
- Rd is H, CN, C1-4 alkyl, or C3-6 cycloalkyl,
- or a pharmaceutically acceptable salt thereof.
17 more elements
A compound having the structure of any of compounds 10-33 as set forth in Table 1.
Dependencies are inferred from the claim text.