High-throughput method to rapidly add chemical moieties to a small molecule library

A compound having a structure:

• wherein:
• when present R1 is-OH or NR2R3, —NR2C(O)R3, R2 and R3 are independently hydrogen, unsubstituted alkyl, or substituted alkyl,
• Z is a small molecule moiety having a molecular weight less than 2,500 Da,
• X is O, NR′, or S,
• QQ is absent, one or more resins, or well plates,
• wherein, when QQ is absent, W1 comprises a carboxyl group, optionally-C(O) OH;
• a carbonyl group, optionally —C(O)R1w);
• an ester, optionally —C(O)OR1w or —OC(O)R1w;
• an amide optionally —C(O)NR2wR3w or —NR2wC(O)R3w;
• a thioester, optionally —C(O)SR4w or —SC(O)R4w;
• a hydrazide, optionally —C(O)NHNH2;
• an amine;
• or a carbinol, optionally —CH2OH,
• wherein, when QQ is present, W1 comprises —OC(O)—, —C(O)O—, —NR2wC(O)—, —NR2w—, —C(O)—, —C(O)S—, —SC(O)—, —NHNHC(O)—, —S—, —O—, or a combination thereof
• wherein R′, R1w-R4w are independently hydrogen, unsubstituted alkyl, substituted alkyl, unsubstituted alkenyl, substituted alkenyl, unsubstituted alkynyl, substituted alkynyl, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted cycloalkyl, substituted cycloalkyl, unsubstituted heterocyclyl, substituted heterocyclyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, unsubstituted heteroaryl, substituted hydroxyamino, or unsubstituted hydroxyamino.