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US 12,576,274 B2Granted
Treating stroke using electrical stimulation
AssigneeUniversity of Washington
InventorsAzadeh Yazdan-Shahmorad, Zixuan Zhou, Karam Khateeb, Mona Rahimi, Aryaman Gala
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Abstract
Techniques for treating acute ischemic stroke, and other neurological pathologies, are described herein. An example method includes identifying a portion of a brain including overactive neurons and outputting an electrical signal to at least one stimulation electrode disposed away from the portion of the brain by a distance in a range of about 0.5 mm to 1 cm. The electrical signal includes a low-frequency component including bursts having a frequency in a range of about 2 Hz to about 10 Hz. The electrical signal includes a high-frequency component comprising pulses having a frequency in a range of about 200 Hz to about 2 kHz.
Claims20
A medical device for treating acute ischemic stroke, the medical device comprising:
- an array of electrocorticography (ECoG) electrodes configured to be disposed on a surface of a brain and comprising:
- at least one monitoring electrode configured to detect, from overactive neurons in the brain, a first electrical signal having a frequency component in a range between 30 Hz and 400 Hz with an amplitude that is above a predetermined threshold;
- and
- at least one stimulation electrode configured to output a treatment signal configured to reduce an activity of the overactive neurons;
- a monitoring circuit coupled to the at least one monitoring electrode and configured to receive signals from the at least one monitoring electrode to detect overactive neurons in the brain, wherein the overactive neurons emit a first electrical signal having a frequency component in a range between 30 Hz and 400 Hz with an amplitude that is above a predetermined threshold;
- and
- a signal generator coupled to the at least one stimulation electrode and configured to cause the at least one stimulation electrode to output a treatment signal configured to reduce an activity of the overactive neurons by outputting, to the at least one stimulation electrode, a second electrical signal that is charge balanced and comprises:
- a low-frequency component comprising bursts having a frequency in a range of about 2 Hertz (Hz) to about 10 Hz;
- a high-frequency component comprising pulses having a frequency in a range of about 200 Hz to about 2 kilohertz (kHz);
- and
- one or more blocks having a duration in a range of about 10 minutes to about 30 minutes.
8 more elements
A medical device, comprising:
- at least one monitoring electrode;
- a monitoring circuit coupled to the at least one monitoring electrode and configured to identify, from signals received from the at least one monitoring electrode, a group of neurons exhibiting overactivity, the group of neurons emitting a first electrical signal having a frequency component in a range between 30 Hz and 400 Hz with an amplitude that is above a predetermined threshold;
- at least one stimulation electrode configured to:
- output a treatment signal configured to reduce an activity of a group of neurons in a brain, the group of neurons outputting a first electrical signal having a frequency component in a range between 30 Hz and 400 Hz with an amplitude that is above a predetermined threshold;
- and
- to be disposed away from the group of neurons exhibiting overactivity by a distance in a range of about 0.5 mm to 3 centimeters (cm);
- and
- a signal generator coupled to the at least one stimulation electrode and configured to output, to cause the at least one stimulation electrode, a to output the treatment signal by outputting a second electrical signal to the at least one stimulation electrode, the second electrical signal comprising:
- a low-frequency component comprising bursts having a frequency in a range of about 2 Hertz (Hz) to about 10 Hz;
- and
- a high-frequency component comprising pulses having a frequency in a range of about 200 Hz to about 2 kilohertz (KHz).
8 more elements
A method, comprising:
- identifying a portion of a brain comprising overactive neurons outputting a first electrical signal having a frequency component in a range between 30 Hz and 400 Hz with an amplitude that is above a predetermined threshold;
- and
- reducing an activity of the overactive neurons by outputting, to at least one stimulation electrode disposed away from the portion of the brain by a distance in a range of about 0.5 mm to 1 centimeter (cm), a second electrical signal comprising:
- a low-frequency component comprising bursts having a frequency in a range of about 2 Hertz (Hz) to about 10 Hz;
- and
- a high-frequency component comprising pulses having a frequency in a range of about 200 Hz to about 2 kilohertz (kHz).
3 more elements
Dependencies are inferred from the claim text.