Engagement component selection for control of bio-psychiatric therapeutic trajectory (BTT)

A method comprising:

• selecting a state phase based on an engagement component, the engagement component having a set of state phases and determinative of the state phase from the set of state phases, the set of state phases corresponding to a cue for presentation to a subject or electrical stimulations applied by an energy application system, the energy application system configured to apply an electrical stimulation to a subject head of the subject for inducing a physiological reaction in the subject, the energy application system having at least a first energy-emitting device and a second energy-emitting device that support directionality of the electrical stimulation across the subject head, the state phases configured to induce a set of physiological reactions from the subject measurable by a sensor, the sensor configured to couple to the subject to detect at least one feature of the physiological reaction of the subject;
• prompting a user device to present the cue to the subject or the energy application system to apply the electrical stimulation to the subject based on the selected state phase, the user device having a user interface, the user device configured to present cues to the subject via the user interface;
• measuring, in response to prompting the user device to present the cue to the subject or the energy application system to apply the electrical stimulation to the subject based on the selected state phase, the set of physiological reactions of the subject using the sensor, the set of physiological reactions induced by the selected state phase;
• determining a subject bio-psychiatric therapeutic trajectory based on the measured set of physiological reactions from the subject, the subject bio-psychiatric therapeutic trajectory generated by mapping the set of physiological reactions from the subject to the state phase, the subject bio-psychiatric therapeutic trajectory being indicative of a physiological state pattern or a cognitive state of the subject;
• determining, based on comparing the subject bio-psychiatric therapeutic trajectory to a plurality of historical bio-psychiatric therapeutic trajectories, a likelihood of at least one aspect of the physiological state pattern, the cognitive state, a mood, or a disease in the subject corresponds to at least one of an aspect-related bio-psychiatric therapeutic trajectory or a disease-related bio-psychiatric therapeutic trajectory from the plurality of historical bio-psychiatric therapeutic trajectories, the physiological state pattern, the cognitive state, the mood, or the disease in the subject matching at least one physiological pattern of the aspect-related bio-psychiatric therapeutic trajectory or the disease-related bio-psychiatric therapeutic trajectory;
• selecting, in response to determining the likelihood of at least one of the physiological state pattern, the cognitive state, the mood, or the disease in the subject, an updated state phase to be presented to the subject to influence the subject bio-psychiatric therapeutic trajectory to match a healthy bio-psychiatric therapeutic trajectory, the updated state phase including at least one of an updated cue, an updated biofeedback, or an updated waveform from the energy application system applied to the subject head;
• measuring a set of stimulation-induced physiological reactions from the subject using the sensor in response to prompting the user device to present the updated cue, the user device to present the updated biofeedback, or the energy application system to apply the updated waveform based on the updated state phase
• determining a modified subject bio-psychiatric therapeutic trajectory based on the stimulation-induced physiological reactions from the subject;
• determining the modified subject bio-psychiatric therapeutic trajectory does not match the healthy bio-psychiatric therapeutic trajectory;
• and
• adjusting, in response to determining the modified subject bio-psychiatric therapeutic trajectory does not match the healthy bio-psychiatric therapeutic trajectory, the updated state phase to make the subject bio-psychiatric therapeutic trajectory match the healthy bio-psychiatric therapeutic trajectory by adjusting the electrical stimulation to the subject head,
• wherein at least one of an intensity, a pulse width, a time applied, or a frequency of the adjusted electrical stimulation is different from the electrical stimulation.

A non-transitory computer-readable storage medium comprising at least one program for execution by one or more processors of a first device, the at least one program including instructions which, when executed by the one or more processors, cause the first device to perform operations comprising:

• selecting a state phase based on an engagement component, the engagement component having a set of state phases and determinative of the state phase from the set of state phases, the set of state phases corresponding to a cue for presentation to a subject or electrical stimulations applied by an energy application system, the energy application system configured to apply an electrical stimulation to a subject head of the subject for inducing a physiological reaction in the subject, the energy application system having at least a first energy-emitting device and a second energy-emitting device that support directionality of the electrical stimulation across the subject head, the state phases configured to induce a set of physiological reactions from the subject measurable by a sensor, the sensor configured to couple to the subject to detect at least one feature of the physiological reaction of the subject;
• prompting a user device to present the cue to the subject or the energy application system to apply the electrical stimulation to the subject based on the selected state phase, the user device having a user interface, the user device configured to present cues to the subject via the user interface;
• measuring, in response to prompting at least one of the user device to present the cue to the subject or the energy application system to apply the electrical stimulation to the subject based on the selected state phase, the set of physiological reactions of the subject using the sensor, the set of physiological reactions induced by the selected state phase;
• determining a subject bio-psychiatric therapeutic trajectory based on the measured set of physiological reactions from the subject, the subject bio-psychiatric therapeutic trajectory generated by mapping the set of physiological reactions from the subject to the state phase, the subject bio-psychiatric therapeutic trajectory being indicative of a physiological state pattern or a cognitive state of the subject;
• determining, based on comparing the subject bio-psychiatric therapeutic trajectory to a plurality of historical bio-psychiatric therapeutic trajectories, a likelihood of at least one aspect of the physiological state pattern, the cognitive state, a mood, or a disease in the subject corresponds to at least one of an aspect-related bio-psychiatric therapeutic trajectory or a disease-related bio-psychiatric therapeutic trajectory from the plurality of historical bio-psychiatric therapeutic trajectories, the physiological state pattern, the cognitive state, the mood, or the disease in the subject matching at least one physiological pattern of the aspect-related bio-psychiatric therapeutic trajectory or the disease-related bio-psychiatric therapeutic trajectory;
• selecting, in response to determining the likelihood of at least one of the physiological state pattern, the cognitive state, the mood, or the disease in the subject, an updated state phase to be presented to the subject to influence the subject bio-psychiatric therapeutic trajectory to match a healthy bio-psychiatric therapeutic trajectory, the updated state phase including at least one of an updated cue, an updated biofeedback, or an updated waveform from the energy application system applied to the subject head;
• measuring a set of stimulation-induced physiological reactions from the subject using the sensor in response to prompting the user device to present the updated cue, the user device to present the updated biofeedback, or the energy application system to apply the updated waveform based on the updated state phase
• determining a modified subject bio-psychiatric therapeutic trajectory based on the stimulation-induced physiological reactions from the subject;
• determining the modified subject bio-psychiatric therapeutic trajectory does not match the healthy bio-psychiatric therapeutic trajectory;
• and
• adjusting, in response to determining the modified subject bio-psychiatric therapeutic trajectory does not match the healthy bio-psychiatric therapeutic trajectory, the updated state phase to make the subject bio-psychiatric therapeutic trajectory match the healthy bio-psychiatric therapeutic trajectory by adjusting the electrical stimulation to the subject head,
• wherein at least one of an intensity, a pulse width, a time applied, or a frequency of the adjusted electrical stimulation is different from the electrical stimulation.