Systems and methods for the conditioning of cerebrospinal fluid

A system for removing a target microorganism from cerebrospinal fluid, comprising:

• a catheter assembly coupled a first fluid pathway and a second fluid pathway t;
• a filter coupled to the catheter assembly;
• wherein the filter is configured to separate a volume of cerebrospinal fluid withdrawing from a patient into a permeate and a retentate;
• wherein the filter is configured to remove the target microorganism from the volume of cerebrospinal fluid;
• and
• a pump configured to withdraw the volume of cerebrospinal fluid from the patient and transfer the volume of cerebrospinal fluid to the filter along the first fluid pathway and return at least a portion of the permeate to the patient along the second fluid pathway.

A system for treating cerebrospinal fluid, comprising:

• a catheter assembly coupled a first fluid pathway for transporting a volume of cerebrospinal fluid from a patient to a filtration system coupled to the catheter assembly and a second fluid pathway for returning filtered cerebrospinal fluid back to the patient;
• wherein the filtration system includes one or more tangential flow filters;
• a pump configured to withdraw the volume of cerebrospinal fluid from the patient and transfer the volume of cerebrospinal fluid to the filtration system along the first fluid pathway;
• wherein the filtration system is configured to separate the volume of cerebrospinal fluid into a permeate and a retentate;
• wherein the filtration system is configured to remove a meningitis-related microorganism from the volume of cerebrospinal fluid;
• and
• wherein the pump is configured the return the permeate to the patient along the second fluid pathway.