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US 12,576,220 B2Granted
Devices, systems and methods for improved radiotherapy efficacy
AssigneeBoston Scientific Scimed, Inc.
InventorAiden Flanagan
Life of this patent
Estimating the term…
Abstract
The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices, systems and methods for improved efficacy of radiotherapy treatment of hypoxic tumors. For example, the disclosed devices, systems and methods may statically or continuously oxygenate hypoxic tumors immediately prior to or simultaneous with irradiation.
Claims20
A medical system, comprising:
- a flexible elongate member;
- an oxygenation element fluidly connected to a proximal end of the flexible elongate member;
- a gas exchange device fluidly connected to a distal end of the flexible elongate member, the gas exchange device comprising an outer tubular member, an inner tubular member disposed within the outer tubular member, and a solid oxygen permeable membrane that is attached to and extends beyond a distal end of the outer tubular member, thereby forming an oxygen diffusing tip of the device, wherein an interior of the outer tubular member is fluidly connected to an interior of the solid oxygen permeable membrane, wherein an interior of the inner tubular member is fluidly connected to the interior of the solid oxygen permeable membrane, and wherein a distal end of the inner tubular member extends into the interior of the solid oxygen permeable membrane;
- an ultrasonic transducer positioned within the interior of the solid oxygen permeable membrane;
- a gas exchange fluid contained within the system and flowable from the oxygenation element to the gas exchange device through a first lumen of the flexible elongate member and flowable from the gas exchange device to the oxygenation element through a second lumen of the flexible elongate member;
- and
- a gas exchange membrane disposed within the oxygenation element, the gas exchange membrane configured to transfer oxygen to the gas exchange fluid.
4 more elements
A medical system, comprising:
- a flexible elongate member;
- an oxygenation element fluidly connected to a proximal end of the flexible elongate member;
- a gas exchange device fluidly connected to a distal end of the flexible elongate member, the gas exchange device comprising an outer tubular member, an inner tubular member disposed within the outer tubular member, and a solid oxygen permeable membrane that is attached to and extends beyond a distal end of the outer tubular member, thereby forming an oxygen diffusing tip of the device, an interior of the outer tubular member fluidly connected to an interior of the solid oxygen permeable membrane, and an interior of the inner tubular member fluidly connected to the interior of the solid oxygen permeable membrane;
- a tubular outer sheath having a porous distal end and an open or closed distal tip, the oxygen diffusing tip configured to be disposed within the tubular outer sheath adjacent the porous distal end;
- a gas exchange fluid contained within the system and flowable from the oxygenation element to the gas exchange device through a first lumen of the flexible elongate member and flowable from the gas exchange device to the oxygenation element through a second lumen of the flexible elongate member;
- and
- a gas exchange membrane disposed within the oxygenation element, the gas exchange membrane configured to transfer oxygen to the gas exchange fluid;
- wherein the tubular outer sheath is configured to be retracted relative to the oxygen diffusing tip, thereby exposing the oxygen diffusing tip;
- and
- wherein a distal end of the inner tubular member extends into the interior of the solid oxygen permeable membrane and wherein an ultrasonic transducer is positioned adjacent an outer surface of the tubular inner sheath.
7 more elements
A medical system, comprising:
- a flexible elongate member;
- an oxygenation element fluidly connected to a proximal end of the flexible elongate member;
- a gas exchange device fluidly connected to a distal end of the flexible elongate member, the gas exchange device comprising an outer tubular member, an inner tubular member disposed within the outer tubular member, and a solid oxygen permeable membrane that is disposed at a distal end of the outer tubular member, thereby forming an oxygen diffusing tip of the device, an interior of the outer tubular member fluidly connected to an interior of the solid oxygen permeable membrane, and an interior of the inner tubular member fluidly connected to the interior of the solid oxygen permeable membrane;
- an ultrasonic transducer positioned within the interior of the solid oxygen permeable membrane;
- a gas exchange fluid contained within the system and flowable from the oxygenation element to the gas exchange device through a first lumen of the flexible elongate member and flowable from the gas exchange device to the oxygenation element through a second lumen of the flexible elongate member;
- and
- a gas exchange membrane disposed within the oxygenation element, the gas exchange membrane configured to transfer oxygen to the gas exchange fluid.
4 more elements
Dependencies are inferred from the claim text.