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US 12,576,192 B2Granted
Multi-layered graft for tissue engineering applications
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Ri.MED Foundation
InventorsAntonio D'Amore, Matteo Solazzo, William R. Wagner
Life of this patent
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Abstract
A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.
Claims19
A multi-layer synthetic graft device comprising:
- a first tubular, porous, biodegradable polymer matrix, the first tubular, porous, biodegradable polymer matrix formed by electrospinning and configured to prevent cellular migration therethrough;
- an ECM gel layer disposed circumferentially about the first porous, biodegradable polymer matrix;
- and
- a second tubular, porous, biodegradable polymer matrix disposed circumferentially about the ECM gel, the second tubular, porous, biodegradable polymer matrix formed by thermally induced phase separation and configured to permit cellular migration therethrough.
1 more element
A method of making a synthetic tubular graft device, comprising:
- forming a first tubular, porous, biodegradable polymer matrix by electrospinning;
- depositing an ECM gel layer over the first tubular, porous, biodegradable polymer matrix to produce a tubular, multi-layer structure;
- and
- inserting the tubular, multi-layer structure into a second, tubular, porous, biodegradable polymer matrix formed by thermal induced phase separation, thereby producing a tubular graft device.
1 more element
Dependencies are inferred from the claim text.