Hyaluronic acid filler having high viscoelasticity and high cohesiveness

A hyaluronic acid hydrogel filler, comprising a crosslinked hyaluronic acid, wherein the filler has a complex viscosity of 60,000 to 130,000 cP at an angular velocity of 1 Hz as measured by a rheometer, a storage elastic modulus G′ of 400 to 800 Pa, and a cohesivity of 30 to 60 gf, wherein the filler comprises a crosslinking agent at a concentration of 1 to 10 mol % based on 1 mol of N-acetyl-D-glucosamine and D-glucuronic acid in the crosslinked hyaluronic acid, and

• wherein the crosslinked hyaluronic acid is one in which a hyaluronic acid having a molecular weight of 2,500,000 Da or more is crosslinked and in the form of particles having an average diameter of 300 to 400 μm,
• a degree of modification (MOD) (%) of the hyaluronic acid as represented by Equation 1 following is in the range of 1 to 7%:
• Degree of modification (%)=total number of moles of crosslinking agent/total number of moles of N-acetyl-D-glucosamine)×100, and [Equation 1]
• a crosslinking ratio (CrR) as represented by Equation 2 is in the range of 0.1 to 0.2:
• Crosslinking ratio=number of moles of crosslinked crosslinking agent/number of moles of total crosslinking agent. [Equation 2]