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US 12,576,171 B2Granted
Composition of radioactive and non-radioactive microparticles
AssigneeABK Biomedical Incorporated
InventorsMarc Gregoire, F. Anthony Headley, Jr.
Life of this patent
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Abstract
The present disclosure provides a composition that includes a mixture of (i) radioactive microparticles; and (ii) non-radioactive microparticles. The radioactive microparticles may be suitable to treat a vascularized tumour, such as a liver tumour or a metastasized liver tumour. The radioactive microparticles and the non-radioactive microparticles may have substantially the same resistance when flowing in a liquid through a conduit. The present disclosure also provides methods of making and methods of using mixtures of microparticles.
Claims21
A composition comprising a mixture of:
- (i) radioactive microparticles;
- and
- (ii) non-radioactive microparticles,
- wherein the non-radioactive microparticles have a level of radioactivity that is less than 0.15 GBq/gram,
- wherein the radioactive microparticles make up from about 10% to about 80% of the total mass of microparticles in the composition,
- wherein the mixture of the radioactive microparticles and the non-radioactive microparticles has an overall specific activity that is 0.4 GBq/g or greater and wherein the radioactive microparticles comprise one or more radioisotopes selected from the group consisting of:
- yttrium-90, phosphorus-32, copper-67, rubidium-82, strontium-89, molybdenum-99, technicium-99m, palladium-103, indium-111, iodine-125, iodine-131, samarium-153, gadolinium-157, holmium-166, lutetium-177, rhenium-186, rhenium-188, tungsten-188, thallium-201, lead-212, bismuth-213, radium-223, and actinium-225.
4 more elements
Dependencies are inferred from the claim text.