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US 12,576,167 B2Granted
Gadolinium-based compound, method for producing same, and MRI contrast agent containing same
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsYong Min Chang, Bo Kyung Sung
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Abstract
The present invention relates to a novel gadolinium-based compound having a structure in which a gadolinium complex and a gallic acid are bonded to each other, a method for producing same, and an MRI contrast agent containing same.
Claims12
A gadolinium-based compound represented by a following Chemical Formula 1:
- wherein in the Chemical Formula 1,
- A represents *—(CH2)n-A1-*,
- n represents any integer from 0 to 5,
- A1 represents *—COO—*, *—CO—*, *—NH—*, *—CH2—*, *—CONH—*, or *—O—*,
- Linker represents *-L1-NHCO-L2-*, *-L1-O—R—O-L2-*, *-L1-CH2-L2-*, *-L1-NH-L2-*, or *-L1-COO-L2-*,
- L1 represents linear or branched (C1-C30)alkyl,
- L2 represents a single bond, hydrogen or linear or branched (C1-C30)alkyl,
- R represents linear or branched (C1-C20)alkyl,
- Ga represents a following Chemical Formula 2:
- * indicates a connection site.
7 more elements
Dependencies are inferred from the claim text.