Back to results
US 12,576,160 B2Granted
Bispecific nanoparticle systems for targeting cancer cells
AssigneeUniversity of Notre Dame du Lac
InventorPrakash Daniel Nallathamby
Life of this patent
Estimating the term…
Abstract
Described herein are compositions and methods for targeting cancer cells and inducing cell death. In one embodiment, the composition comprises a nanoparticle system comprising a plurality of antibodies that recognize CAR-T cells and a plurality of antibodies that recognize cancer cells. The composition targets CAR-T cells to the vicinity of cancer cells, whereby upon activation, the CAR-T cells can effectuate cancer cell death.
Claims12
A therapeutic composition comprising:
- a nanoparticle system comprising a silicon dioxide core and a plurality of gold nanospheres on the surface of the silicon dioxide core, the silicon dioxide core being selectively conjugated to one or more tumor cell targeting antibodies and the plurality of gold nanospheres being selectively conjugated to one or more T-cell targeting antibodies.
Dependencies are inferred from the claim text.