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US 12,576,157 B2Granted
Peptide saporin conjugate for the treatment of cancer
AssigneeSRI International
InventorsKathlynn C. Brown, Curtis Allred, Michael McGuire
Life of this patent
Estimating the term…
Abstract
Disclosed herein, are compositions comprising one or more a molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.
Claims8
A molecular guidance system (MGS) peptide of amino acid sequence selected from CH3CO-FHAVPQSFYT-PEG11-C-NH2 (SEQ ID No:
- 76), and FHAVPQSFY (SEQ ID NO:
- 78).
A composition comprising one or more cytotoxic agents conjugated to one or more molecular guidance system (MGS) peptides selected from:
- LQWRRNFGVWARYRL (SEQ ID NO:
- 31), CH3CO-LQWRRNFGVWARYRL, CH3CO-LQWRRNFGVWARYRL-PEG11-C-NH2 (SEQ ID NO:
- 72), CH3CO-FHAVPQSFYT-PEG11-C-NH2 (SEQ ID NO:
- 76), FHAVPQSFY (SEQ ID NO:
- 78), and CH3CO-YAAWPASGAWT-PEG11-C-NH2 (SEQ ID NO:
- 71).
3 more elements
Dependencies are inferred from the claim text.