Vaccines against Powassan virus, and methods of using same
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsKar Muthumani, David Weiner, Hyeree Choi, Sagar B. Kudchodkar
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Abstract
An aspect of the present invention is related to nucleic acid constructs capable of expressing at least one Powassan virus (POWV) antigen that elicits an immune response in a mammal against POWV virus, and methods of use thereof.
Claims16
An immunogenic composition comprising a nucleic acid molecule encoding at least one consensus Powassan virus (POWV) antigen, wherein the POWV antigen is selected from the group consisting of a premembrane-envelope (prME) antigen, a capsid antigen, and a combination thereof, and wherein the nucleic acid molecule encodes a peptide comprising an amino acid sequence selected from the group consisting of
- a) an amino acid sequence having at least 98% identity over the entire length of SEQ ID NO:
- 10, and
- b) the amino acid sequence selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 6 and SEQ ID NO:
- 10;
- wherein the immunogenic composition comprises an adjuvant.
A peptide comprising an amino acid sequence selected from the group consisting of
- a) an amino acid sequence having at least 98% identity over the entire length of SEQ ID NO:
- 10, and
- b) the amino acid sequence selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, SEQ ID NO:
- 10 and SEQ ID NO:
- 12;
- wherein the immunogenic composition comprises an adjuvant.
Dependencies are inferred from the claim text.