Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase
AssigneeJulius-Maximilians-UniversitäT WüRzburg
InventorsLorenz Meinel, Tessa Lühmann, Alexandra Braun
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Abstract
The present invention relates to compounds and their use in the treatment of lesions, in tissue regeneration and/or tissue engineering. The compounds act as substrates for enzymes having transglutaminase activity and are suitable for their immobilization and/or attached therapeutic or diagnostic molecules on extracellular matrix (ECM) or synthetic ECM-derived materials, in particular for the immobilization of myostatin inhibitors.
Claims11
A synthetic compound suitable for transglutaminase-mediated binding or attachment or incorporation of a therapeutic and/or diagnostic molecule into an extracellular matrix or a synthetic extracellular matrix component, wherein said compound comprises
- (a) at least one anchor domain and
- (b) at least one second domain, wherein said second domain possesses therapeutic and/or preventive activity,
- wherein said anchor domain is the isolated D domain of Insulin Growth Factor-1 (IGF-I) as depicted in SEQ ID NO:
- 1,
- wherein said isolated D domain does not comprise the growth factor activity of IGF-I,
- wherein said anchor domain is capable of binding to an extracellular matrix or a synthetic extracellular matrix component;
- wherein said second domain is directly or indirectly linked to the anchor domain, and
- wherein said second domain comprises the amino acid sequence as defined in SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.