Antigen-binding agents that specifically bind epidermal growth factor receptor variant III

An antigen-binding agent comprising an antigen-binding domain of an antibody that specifically binds to epidermal growth factor receptor variant III (EGFRvIII), wherein the antigen-binding domain comprises:

• a. a CDRL1 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:
• 15, a CDRL2 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:16, a CDRL3 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:
• 17, a CDRH1 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:19, a CDRH2 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:20 and a CDRH3 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:21;
• b. a CDRL1 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:
• 7, a CDRL2 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:8, a CDRL3 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:9, a CDRH1 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:11, a CDRH2 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:12 and a CDRH3 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:13, or
• c. a CDRL1 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:
• 23, a CDRL2 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:24, a CDRL3 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:25, a CDRH1 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:27, a CDRH2 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:28 and a CDRH3 comprising or consisting essentially of the amino acid sequence set forth in SEQ ID NO:29.