Back to results
US 12,576,131 B2Granted
Altering inflammatory states of immune cells in vivo by modulating cellular activation states
AssigneeFred Hutchinson Cancer Center
InventorMatthias Stephan
Life of this patent
Estimating the term…
Abstract
Systems and methods to modulate the activation state of immune cells in vivo are described. The systems and methods can be used to transform immunosuppressive macrophages that support cancer growth and metastasis into highly activated tumoricidal macrophages.
Claims14
A therapeutic composition comprising nanoparticles comprising mRNA encoding interferon regulatory factor 5 (IRF5) and mRNA encoding IKKβ.
Dependencies are inferred from the claim text.