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US 12,576,130 B2Granted
Dominant negative SARM1 molecules comprising a substitution at position 189, 190, 193, 194, 570 and/or 685 of SARM1
AssigneeWashington University
InventorsAaron DiAntonio, Jeffrey D. Milbrandt, Daniel Summers, Stefanie Geisler, Xianrong Mao
Life of this patent
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Abstract
The present invention provides compositions useful as inhibitors of SARM1 activity, pharmaceutical compositions thereof, and methods of using the same. The present invention provides dominant negative SARM1 molecules useful for treating a neurodegenerative or neurological disease or disorder, pharmaceutical compositions thereof, and methods of using the same.
Claims9
A mutant human sterile alpha and TIR motif containing protein 1 (SARM1) polypeptide, comprising the amino acid sequence of SEQ ID NO:1 and having
- an amino acid substitution selected from K193A, K193E, K193M, K193Q, and K193R relative to SEQ ID NO:1;
- an amino acid substitution selected from H685Y and H685A relative to SEQ ID NO:
- 1;
- amino acid substitutions K193R and H685A relative to SEQ ID NO:1;
- amino acid substitutions K193R, H194A, and H685A relative to SEQ ID NO:1;
- an amino acid substitution E189K relative to SEQ ID NO:1;
- an amino acid substitution R570A relative to SEQ ID NO:
- 1;
- or
- an amino acid substitution H190A relative to SEQ ID NO:1.
7 more elements
Dependencies are inferred from the claim text.