Antiproliferative effect of agarophyton chilensis extract in prostate cancer
AssigneesUniversidad AndréS Bello, Universidad San Sebastian
InventorsFrancisca Bronfman, Alejandro Godoy, Camila Schmidt, Loretto Contreras
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Abstract
The invention relates to a pharmaceutical composition of an extract of Agarophyton chilensis, with antiproliferative effect in prostate cancer, comprising (a) 0.1 to 90% of an oleoresin of Agarophyton chilensis, with the following major components: palmitic acid, arachidonic acid, oleic acid, stearic acid, meristic acid, linoleic acid; and (b) 10 to 99.9% excipients and formulation aids for different pharmaceutical forms. And its use to prepare a drug for the treatment or prevention of prostate cancer and other hyperproliferative states of prostate tissue cells.
Claims5
A pharmaceutical composition, comprising:
- (a) 0.1 to 90% by weight of an oleoresin of Agarophyton chilensis as an active ingredient, based on a total weight of the pharmaceutical composition, wherein the oleoresin of Agarophyton chilensis comprises 35 to 45% by weight of palmitic acid, 14 to 25% by weight of arachidonic acid, 9 to 20% by weight of oleic acid, 2 to 8% by weight of stearic acid, 2 to 8% by weight of myristic acid, and 2 to 8% by weight of linoleic acid, based on a total weight of the oleoresin of Agarophyton chilensis;
- and
- (b) 10 to 99.9% by weight of a total amount of an additional material based on the total weight of the pharmaceutical composition,
- wherein the oleoresin of Agarophyton chilensis further comprises docosahexaenoic acid (DHA),
- wherein the additional material comprises:
- a pharmaceutically acceptable excipient and formulation aid, and a pharmaceutically acceptable preservative,
- the pharmaceutically acceptable excipient and formulation aid is at least one material selected from the group consisting of mineral oil, vegetable oil, and a preservative,
- wherein the vegetable oil is at least one oil selected from the group consisting of soybean oil, olive oil, sesame oil, and castor oil, and
- the preservative is at least one material selected from citric acid, methyl paraben, and a propyl paraben, and
- wherein the pharmaceutical composition is in a form of a syrup, a pill, a tablet, an injectable solution, a gel, a cream, or an ointment.
Dependencies are inferred from the claim text.