Antiviral agent
AssigneeTohoku University
InventorsHaruki Kitazawa, Hisashi Aso, Wakako Ohtsubo
Life of this patent
Estimating the term…
Abstract
A problem of the invention is to provide an antiviral agent containing as an active ingredient a probiotic which effectively exhibits an antiviral effect also on combined infection with a virus and a pathogenic bacterium. An agent containing one, two or more Lactobacillus strains which have 16S rRNA gene having an identity of at least 90% with the nucleotide sequence of SEQ ID NO: 1 and which have the action of enhancing the expression of an antiviral factor and/or the action of reducing the expression of a downregulator of an antiviral factor is used as an antiviral agent.
Claims12
A method for preventing or treating rotavirus infection, comprising a step of administering to a subject in need of prevention or treatment of rotavirus infection one or more Lactobacillus strains selected from the group consisting of:
- a Lactobacillus salivarius strain deposited under accession number NITE BP-03218;
- a Lactobacillus salivarius strain deposited under accession number NITE BP-03219;
- a Lactobacillus salivarius strain deposited under accession number NITE BP-03221;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03466;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03467;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03468;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03469;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03470;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03471;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03472;
- a Lactobacillus plantarum strain deposited under accession number NITE BP-03474;
- and
- a Lactobacillus mucosae strain deposited under accession number NITE BP-03473,
- wherein the administering of one or more Lactobacillus strains has an action of enhancing expression of an antiviral factor and/or an action of reducing expression of a downregulator of an antiviral factor.
Dependencies are inferred from the claim text.