Ribose-modified cap analog and use thereof
AssigneeBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd.
InventorsHonglei Zhang, Gengshen Song, Yangjian Liu, Kai Dong, Yuqing Ma, Chao Zhang, Yanfeng Wang, Guoliang Zhang, Lili Jiang, Jinyu Zhang
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Abstract
The present disclosure provides a ribose-modified cap analog and a use thereof, and belongs to the technical field of chemical and biological engineering. The ribose-modified cap analog has a structure of formula (I). The ribose-modified cap analog described herein can improve the stability of mRNA and/or the translation efficiency of mRNA.
Claims5
A ribose-modified cap analog or a pharmaceutically acceptable salt thereof, wherein the ribose-modified cap analog has a structure of YK-CAP-106, YK-CAP-107, YK-CAP-108, YK-CAP-109, YK-CAP-110, YK-CAP-111, YK-CAP-112, YK-CAP-113, YK-CAP-114, YK-CAP-115, YK-CAP-116, YK-CAP-117, YK-CAP-118, or YK-CAP-119 as shown below:
Dependencies are inferred from the claim text.